Since the discovery of the DNA double helix, there has been a fascination in understanding
the molecular mechanisms and cellular processes that account for:(i) the transmission of …

Over the past century, studies of human pigmentary disorders along with mouse and
zebrafish models have shed light on the many cellular functions associated with visible …

Synthetic lethality—an interaction between two genetic events through which the co-
occurrence of these two genetic events leads to cell death, but each event alone does not …

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature
aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase …

RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and
animals. These helicases play important roles in multiple cellular functions, including DNA …

Osteosarcoma (OS) is the most common primary bone tumor affecting predominantly
adolescents and young adults. It accounts for about 5% of all childhood cancers. Although …

During evolution, cells have developed a wide spectrum of stress response modules to
ensure homeostasis. The genome and proteome damage response pathways constitute the …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Histone variants, present in various cell types and tissues, are known to exhibit different
functions. For example, histone H3. 3 and H2A. Z are both involved in gene expression …

Cellular senescence caused by oncogenic stimuli is associated with the development of
various age-related pathologies through the senescence-associated secretory phenotype …