Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which
causes many severe acute and chronic infections with high morbidity, and mortality rates as …

The prevention, diagnosis, and management of infectious disease in transplantation are
major contributors to improved outcomes in organ transplantation. The risk of serious …

Thousands of pathogens are known to infect humans, but only a fraction are readily
identifiable using current diagnostic methods. Microbial cell-free DNA sequencing offers the …

Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate
environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment …

Primary CNS lymphoma (PCNSL) harbors mutations that reinforce B cell receptor (BCR)
signaling. Ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, targets BCR signaling and is …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis can be caused by a broad range of pathogens; however, bacterial …

Differences in susceptibility to immune-mediated diseases are determined by variability in
immune responses. In three studies within the Human Functional Genomics Project, we …

Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …

Infectious Diseases Society of America (IDSA), the Surgical Infection Society (SIS), and the
Society for Healthcare Epidemiology of America (SHEA). This work represents an update to …

The application of sequencing technology is shifting from research to clinical laboratories
owing to rapid technological developments and substantially reduced costs. However …