Obligately intracytosolic rickettsiae that cycle between arthropod and vertebrate hosts cause
human diseases with a spectrum of severity, primarily by targeting microvascular endothelial …

Macrophages are prevalent in the body and have roles in almost every aspect of human
biology. They have often been considered a subject to avoid during drug delivery. However …

Once feared as a deadly intracellular bacterium with the extraordinary capacity to survive a
wide array of arduous external stressors, Listeria monocytogenes is increasingly recognized …

Salmonella enterica serotype Typhimurium causes an acute inflammatory reaction in the
ceca of streptomycin-pretreated mice. We determined global changes in gene expression …

The generation of reactive oxygen species (ROS) is inherent to immune responses. ROS are
crucially involved in host defense against pathogens by promoting bacterial killing, but also …

Bacterial pathogens residing in host macrophages in intracellular infections are hard to
eradicate because traditional antibiotics do not readily enter the cells or get eliminated via …

It could be argued that we understand the immune response to infection with Listeria
monocytogenes better than the immunity elicited by any other bacteria. L. monocytogenes …

The acute nature of disease outbreaks in aquaculture settings has served to emphasize the
importance of the innate immune response of fish for survival and led to the recent …

IFNγ produced by intraperitoneal myeloid and NK cells during cecal ligation/puncture-
induced septic shock facilitates myeloid cell activation yet blockade of IFNγ does not …

Acinetobacter baumannii is an important cause of both community-associated and
nosocomial pneumonia, which have become increasingly difficult to treat because of the …