[HTML][HTML] Macrophages in immunoregulation and therapeutics

S Chen, AFUH Saeed, Q Liu, Q Jiang, H Xu… - … and Targeted Therapy, 2023 - nature.com
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

[HTML][HTML] Metabolism, metabolites, and macrophages in cancer

M Li, Y Yang, L Xiong, P Jiang, J Wang, C Li - Journal of Hematology & …, 2023 - Springer
Tumour-associated macrophages (TAMs) are crucial components of the tumour
microenvironment and play a significant role in tumour development and drug resistance by …

[HTML][HTML] Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)

YY Qiu, J Zhang, FY Zeng, YZ Zhu - Pharmacological Research, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease phenotypes
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …

Bacteria‐Derived Outer‐Membrane Vesicles Hitchhike Neutrophils to Enhance Ischemic Stroke Therapy

J Pan, Z Wang, X Huang, J Xue, S Zhang… - Advanced …, 2023 - Wiley Online Library
The treatment of reperfusion injury after ischemic stroke remains unsatisfactory since the
blood‐brain barrier (BBB) prevents most neuroprotective agents from entering the brain …

[HTML][HTML] A new perspective on NAFLD: Focusing on the crosstalk between peroxisome proliferator-activated receptor alpha (PPARα) and farnesoid X receptor (FXR)

S Zhou, H You, S Qiu, D Yu, Y Bai, J He, H Cao… - Biomedicine & …, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is primarily caused by abnormal lipid metabolism
and the accumulation of triglycerides in the liver. NAFLD is also associated with hepatic …

[HTML][HTML] Signal pathways in the treatment of Alzheimer's disease with traditional Chinese medicine

MR Ding, YJ Qu, B Hu, HM An - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Aim of the review This study aimed to reveal the classical signal pathways and important
potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD) …

[PDF][PDF] Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene

J Lopez-Tello, HEJ Yong, I Sandovici, GKC Dowsett… - Cell Metabolism, 2023 - cell.com
Maternal-offspring interactions in mammals involve both cooperation and conflict. The fetus
has evolved ways to manipulate maternal physiology to enhance placental nutrient transfer …

[HTML][HTML] Peroxisome proliferator-activated receptors and the hallmarks of cancer

N Wagner, KD Wagner - Cells, 2022 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) function as nuclear transcription factors
upon the binding of physiological or pharmacological ligands and heterodimerization with …

Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's …

Q Zheng, H Liu, H Zhang, Y Han, J Yuan… - Advanced …, 2023 - Wiley Online Library
Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's
disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting …

Sepsis: a failing starvation response

J Vandewalle, C Libert - Trends in Endocrinology & Metabolism, 2022 - cell.com
Sepsis is involved in~ 20% of annual global deaths. Despite decades of research, the
current management of sepsis remains supportive rather than curative. Clinical trials in …