Cardiovascular disease (CVD) poses the leading threats to human health and life, and their
occurrence and severity are associated with exposure to environmental pollutants. Per-and …

The main hallmark of myocardial substrate metabolism in cardiac hypertrophy or heart
failure is a shift from fatty acid oxidation to greater reliance on glycolysis. However, the close …

Immune checkpoint inhibitors (ICIs) have shown promising therapeutic effects in the
treatment of advanced solid cancers, but their overall response rate is still very low for …

Primary hyperlipidemias include a heterogeneous set of monogenic and polygenic
conditions characterized by a strong family aggregation, severe forms of …

As ubiquitous emerging pollutants, microplastics (MPs) in aquatic environments have
aroused critical global concerns. Despite the occurrence and characteristics of MPs in …

The kidney is a highly metabolic organ and requires a large amount of ATP to maintain its
filtration-reabsorption function, and mitochondrial fatty acid β-oxidation serves as the main …

Liver cancer or hepatocellular carcinoma (HCC) is leading cause of cancer-related
mortalities globally. The therapeutic approaches for chronic liver diseases-associated liver …

The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …

The lipid-sensing transcription factor PPARγ is the target of antidiabetic thiazolidinediones
(TZD). At two sites within its ligand binding domain, it also binds oxidized vitamin E …

Weak tissue adhesion remains a major challenge in clinical translation of microneedle
patches. Mimicking the structural features of honeybee stingers, stiff polymeric microneedles …