T cells are required for immune surveillance of the central nervous system (CNS); however,
they can also induce severe immunopathology in the context of both viral infections and …

The autoimmune model of multiple sclerosis (MS) pathogenesis provided for many years a
useful but incomplete conceptual framework for understanding the complex array of factors …

As a group of disorders, autoimmunity ranks as the third most prevalent cause of morbidity
and mortality in the W estern W orld. However, the etiology of most autoimmune diseases …

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated inflammatory
disorder of the CNS characterized by a widespread demyelination that predominantly …

Epstein-Barr virus (EBV), a ubiquitous B-lymphotropic herpesvirus, has been associated
with multiple sclerosis (MS), an inflammatory disease of the central nervous system (CNS) …

Type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) are the most frequent
chronic autoimmune diseases worldwide. Several autoimmune endocrine and non …

The predisposition of individuals to several common autoimmune diseases, such as
rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis, is genetically …

Objective To characterize the association between infectious mononucleosis (IM), a frequent
clinical manifestation of primary Epstein–Barr virus infection after childhood, and the risk for …

A better understanding of immune-mediated mechanisms in the pathogenesis of multiple
sclerosis and the contribution of environmental risk factors toward the development of …

Multiple sclerosis (MS) is an immune inflammatory disease, where the underlying etiological
cause remains elusive. Multiple triggering factors have been suggested, including …