There is increasing evidence that infection with the Epstein-Barr virus (EBV) plays a role in
the development of multiple sclerosis (MS), a chronic inflammatory demyelinating disease of …

T cell receptor (TCR) binding degeneracy lies at the heart of several physiological and
pathological phenomena, yet its structural basis is poorly understood. We determined the …

Epidemiological data suggest that the Epstein-Barr virus (EBV) is associated with several
autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and …

Autoimmune T and B cell responses to CNS antigen (s) are thought to drive the
pathogenesis of multiple sclerosis (MS), and thus are logical targets for therapy. Indeed …

Genetic and environmental factors jointly determine the susceptibility to develop Multiple
Sclerosis (MS). Collaborative efforts during the past years achieved substantial progress in …

Epstein–Barr virus (EBV) is a human herpesvirus hiding in a latent form in memory B cells in
the majority of the world population. Although, primary EBV infection is asymptomatic or …

Introduction Multiple sclerosis (MS) is a complex genetic disease characterized by chronic
inflammation of the central nervous system (CNS). The pathology of MS is largely attributed …

T lymphocytes play a central role in the pathogenesis of multiple sclerosis (MS)(Zhang et al.,
1992). Both CD4+ and CD8+ T cells have been demonstrated in MS lesions, with CD4+ T …

Genes in the major histocompatibility complex (MHC) encode proteins important in
activating antigen-specific immune responses. Alleles at adjacent MHC loci are often in …

This report describes the design of the eplet version of HLAMatchmaker to determine class II
compatibility at the structural level. This matching algorithm is based on the hypothesis …