RNAi-based therapeutics and tumor targeted delivery in cancer
Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …
for the development of targeted therapies for cancer and other diseases. The discovery of …
Advances in the delivery of RNA therapeutics: from concept to clinical reality
The rapid expansion of the available genomic data continues to greatly impact biomedical
science and medicine. Fulfilling the clinical potential of genetic discoveries requires the …
science and medicine. Fulfilling the clinical potential of genetic discoveries requires the …
RNA-based diagnostic and therapeutic strategies for cardiovascular disease
D Lu, T Thum - Nature Reviews Cardiology, 2019 - nature.com
Cardiovascular diseases are the leading cause of death globally and are associated with
increasing financial expenditure. With the availability of next-generation sequencing …
increasing financial expenditure. With the availability of next-generation sequencing …
MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches
The deeper understanding of non-coding RNAs has recently changed the dogma of
molecular biology assuming protein-coding genes as unique functional biological effectors …
molecular biology assuming protein-coding genes as unique functional biological effectors …
[HTML][HTML] Chitosan-based nanoparticles against viral infections
H Boroumand, F Badie, S Mazaheri… - Frontiers in cellular …, 2021 - frontiersin.org
Viral infections, in addition to damaging host cells, can compromise the host immune
system, leading to frequent relapse or long-term persistence. Viruses have the capacity to …
system, leading to frequent relapse or long-term persistence. Viruses have the capacity to …
[HTML][HTML] Connective tissue growth factor: from molecular understandings to drug discovery
Z Chen, N Zhang, HY Chu, Y Yu, ZK Zhang… - Frontiers in cell and …, 2020 - frontiersin.org
Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved
in different biological processes, such as cell proliferation, angiogenesis, and wound …
in different biological processes, such as cell proliferation, angiogenesis, and wound …
Protein degradation technology: a strategic paradigm shift in drug discovery
Targeting pathogenic proteins with small-molecule inhibitors (SMIs) has become a widely
used strategy for treating malignant tumors. However, most intracellular proteins have been …
used strategy for treating malignant tumors. However, most intracellular proteins have been …
Robust delivery of RIG‐I agonists using extracellular vesicles for anti‐cancer immunotherapy
The RIG‐I pathway can be activated by RNA containing 5′ triphosphate, leading to type I
interferon release and immune activation. Hence, RIG‐I agonists have been used to induce …
interferon release and immune activation. Hence, RIG‐I agonists have been used to induce …
Role of biologics and biosimilars in inflammatory bowel disease: current trends and future perspectives
Inflammatory bowel disease (IBD) is an idiopathic chronic inflammatory disease of the
gastrointestinal system. The spectrum is of predominantly two types, namely, ulcerative …
gastrointestinal system. The spectrum is of predominantly two types, namely, ulcerative …
Emerging technologies for low‐cost, rapid vaccine manufacture
To stop the spread of future epidemics and meet infant vaccination demands in low‐and
middle‐income countries, flexible, rapid and low‐cost vaccine development and …
middle‐income countries, flexible, rapid and low‐cost vaccine development and …