Advanced situation with recombinant toxins: Diversity, production and application purposes
E Efremenko, A Aslanli, I Lyagin - International Journal of Molecular …, 2023 - mdpi.com
Today, the production and use of various samples of recombinant protein/polypeptide toxins
is known and is actively developing. This review presents state-of-the-art in research and …
is known and is actively developing. This review presents state-of-the-art in research and …
Cellular Uptake and Cytotoxicity of Clostridium perfringens Iota-Toxin
M Nagahama, M Takehara, S Seike, Y Sakaguchi - Toxins, 2023 - mdpi.com
Clostridium perfringens iota-toxin is composed of two separate proteins: a binding protein
(Ib) that recognizes a host cell receptor and promotes the cellular uptake of a catalytic …
(Ib) that recognizes a host cell receptor and promotes the cellular uptake of a catalytic …
Alpha-1 antitrypsin inhibits Clostridium botulinum C2 toxin, Corynebacterium diphtheriae diphtheria toxin and B. anthracis fusion toxin
S Lietz, LM Sokolowski, H Barth, K Ernst - Scientific Reports, 2024 - nature.com
The bacterium Clostridium botulinum, well-known for producing botulinum neurotoxins,
which cause the severe paralytic illness known as botulism, produces C2 toxin, a binary AB …
which cause the severe paralytic illness known as botulism, produces C2 toxin, a binary AB …
[HTML][HTML] Clostridium botulinum C3 toxin for selective delivery of cargo into dendritic cells and macrophages
M Fellermann, M Stemmer, R Noschka, F Wondany… - Toxins, 2022 - mdpi.com
The protein toxin C3bot from Clostridium botulinum is a mono-ADP-ribosyltransferase that
selectively intoxicates monocyte-derived cells such as macrophages, osteoclasts, and …
selectively intoxicates monocyte-derived cells such as macrophages, osteoclasts, and …
Repurposing FDA-approved disulfiram for targeted inhibition of diphtheria toxin and the binary protein toxins of Clostridium botulinum and Bacillus anthracis
J Borho, M Kögel, A Eckert, H Barth - Frontiers in Pharmacology, 2024 - frontiersin.org
Many bacteria act pathogenic by the release of AB-type protein toxins that efficiently enter
human or animal cells and act as enzymes in their cytosol. This leads to disturbed cell …
human or animal cells and act as enzymes in their cytosol. This leads to disturbed cell …
The Clostridium botulinum C2 Toxin Subunit C2IIa Delivers Enzymes with Positively Charged N-Termini into the Cytosol of Target Cells
S Heber, J Borho, N Stadler, F Wondany, I König… - Toxins, 2023 - mdpi.com
The binary Clostridium (C.) botulinum C2 toxin consists of two non-linked proteins. The
proteolytically activated binding/transport subunit C2IIa forms barrel-shaped …
proteolytically activated binding/transport subunit C2IIa forms barrel-shaped …
Effect of human complement proteins on the activity of binary bacterial toxins of Clostridium botulinum and Bacillus anthracis
J Wohlfart - 2024 - oparu.uni-ulm.de
C2 toxin from Clostridium botulinum and lethal toxin from Bacillus anthracis are both
composed of an enzymatically active A component and a pore-forming B component. These …
composed of an enzymatically active A component and a pore-forming B component. These …