Brain diseases, such as brain tumors, neurodegenerative diseases, cerebrovascular
diseases, and brain injuries, are caused by various pathophysiological changes, which pose …

Natural living materials serving as biotherapeutics exhibit great potential for treating various
diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this …

Introduction A major challenge in treating central nervous system (CNS) disorders is to
achieve adequate drug delivery across the blood–brain barrier (BBB). Receptor-mediated …

Intravenous administration of drugs is a widely used cancer therapy approach. However, the
efficacy of these drugs is often hindered by various biological barriers, including circulation …

Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy's disease, is a
debilitating neuromuscular disease characterized by progressive muscular weakness and …

Recruiting endogenous stem cells and achieving controlled drug release are crucial for in
situ bone regeneration. However, it remains challenging to design functional platforms that …

Sanghuang, a traditional Chinese medicinal herb obtained from numerous related fungal
species in the genus Sanghuangporus, contains many bioactive substances that display a …

Glioblastoma (GBM) is the most aggressive primary brain tumor with low survival rate.
Currently, temozolomide (TMZ) is the first-line drug for GBM treatment of which efficacy is …

Although there are various advancements in biomedical in the past few decades, there are
still challenges in the treatment of brain diseases. The main difficulties are the inability to …

One of the main concerns in oligonucleotide-based therapeutics is achieving a successful
cell targeting while avoiding drug degradation and clearance. Nanoparticulated drug …