Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches
IA Savin, MA Zenkova, AV Sen'kova - International journal of molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …
Hypoxia and hypoxia-inducible factors in kidney injury and repair
S Shu, Y Wang, M Zheng, Z Liu, J Cai, C Tang, Z Dong - Cells, 2019 - mdpi.com
Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal
function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI …
function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI …
Defining physiological normoxia for improved translation of cell physiology to animal models and humans
TP Keeley, GE Mann - Physiological reviews, 2019 - journals.physiology.org
The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
Signalling pathways involved in hypoxia‐induced renal fibrosis
M Liu, X Ning, R Li, Z Yang, X Yang… - Journal of Cellular …, 2017 - Wiley Online Library
Renal fibrosis is the common pathological hallmark of progressive chronic kidney disease
(CKD) with diverse aetiologies. Recent researches have highlighted the critical role of …
(CKD) with diverse aetiologies. Recent researches have highlighted the critical role of …
Hypoxia in tissue repair and fibrosis
IA Darby, TD Hewitson - Cell and tissue research, 2016 - Springer
Hypoxia and hypoxia signalling through the transcription factor hypoxia inducible factor-1
(HIF-1), play an important role in normal tissue repair processes. Tissue injury generally …
(HIF-1), play an important role in normal tissue repair processes. Tissue injury generally …
[HTML][HTML] Role of SARS-COV-2 and ACE2 in the pathophysiology of peripheral vascular diseases
The occurrence of a novel coronavirus known as severe acute respiratory syndrome-
coronavirus-2 (SARS-CoV-2), created a serious challenge worldwide. SARS-CoV-2 has …
coronavirus-2 (SARS-CoV-2), created a serious challenge worldwide. SARS-CoV-2 has …
Lipid droplets: a key cellular organelle associated with cancer cell survival under normoxia and hypoxia
S Koizume, Y Miyagi - International journal of molecular sciences, 2016 - mdpi.com
The Warburg effect describes the phenomenon by which cancer cells obtain energy from
glycolysis even under normoxic (O2-sufficient) conditions. Tumor tissues are generally …
glycolysis even under normoxic (O2-sufficient) conditions. Tumor tissues are generally …
Shared features of endothelial dysfunction between sepsis and its preceding risk factors (aging and chronic disease)
JF Bermejo-Martin, M Martín-Fernandez… - Journal of clinical …, 2018 - mdpi.com
Acute vascular endothelial dysfunction is a central event in the pathogenesis of sepsis,
increasing vascular permeability, promoting activation of the coagulation cascade, tissue …
increasing vascular permeability, promoting activation of the coagulation cascade, tissue …
Impact of skin tone on photoacoustic oximetry and tools to minimize bias
Y Mantri, JV Jokerst - Biomedical Optics Express, 2022 - opg.optica.org
The major optical absorbers in tissue are melanin and oxy/deoxy-hemoglobin, but the
impact of skin tone and pigmentation on biomedical optics is still not completely understood …
impact of skin tone and pigmentation on biomedical optics is still not completely understood …
Hypoxia-inducible factors: key regulators of myeloid cells during inflammation
Hypoxia is a prominent characteristic of many acute or chronic inflammatory diseases, and
exerts significant influence on their progression. Macrophages and neutrophils are major …
exerts significant influence on their progression. Macrophages and neutrophils are major …