A fundamental tenet of inheritance in sexually reproducing organisms such as humans and
laboratory mice is that gametes combine randomly at fertilization, thereby ensuring a …

In the testis, cell adhesion and junctional molecules permit specific interactions and
intracellular communication between germ and Sertoli cells and apposed Sertoli cells …

Mouse models provide a valuable tool for exploring pathogenic mechanisms underlying
inherited human disease. Here, we describe seven mouse models identified through the …

Phenotype-driven mutagenesis is an unbiased method to identify novel genes involved in
spermatogenesis and other reproductive processes. Male repro29/repro29 mice generated …

The study of mutations that impact fertility has a catch‐22. Fertility mutants are often lost
since they cannot simply be propagated and maintained. This has hindered progress in …

Sexual reproduction is used by many different organisms to create a new generation of
genetically distinct progeny. Cells originating from separate sexes or mating types segregate …

Genome-wide mutagenesis was performed in mice to identify candidate genes for male
infertility, for which the predominant causes remain idiopathic. Mice were mutagenized using …

Contents The article presents multi‐species, genome‐wide, comparative approach to review
male fertility‐associated loci to contribute to the development of new genetic markers that …

Tuberoinfundibular peptide of 39 residues (TIP39) was identified as a PTH 2 receptor ligand.
We report that mice with deletion of Tifp39, the gene encoding TIP39, are sterile. Testes …

Fertility can be defined as the natural capability of giving life. It is an important factor both for
human medicine, where~ 10% of the couples call for the services of assisted reproductive …