Cannabinoid receptors and the endocannabinoid system: signaling and function in the central nervous system

S Zou, U Kumar - International journal of molecular sciences, 2018 - mdpi.com
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled …

Keep off the grass? Cannabis, cognition and addiction

HV Curran, TP Freeman, C Mokrysz… - Nature Reviews …, 2016 - nature.com
In an increasing number of states and countries, cannabis now stands poised to join alcohol
and tobacco as a legal drug. Quantifying the relative adverse and beneficial effects of …

The cooccurring use and misuse of cannabis and tobacco: a review

A Agrawal, AJ Budney, MT Lynskey - Addiction, 2012 - Wiley Online Library
Aims Cannabis and tobacco use and misuse frequently cooccur. This review examines the
epidemiological evidence supporting the lifetime cooccurrence of cannabis and tobacco …

Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

S Stringer, CC Minică, KJH Verweij, H Mbarek… - Translational …, 2016 - nature.com
Cannabis is the most widely produced and consumed illicit psychoactive substance
worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence …

The genetics of addiction—a translational perspective

A Agrawal, KJH Verweij, NA Gillespie, AC Heath… - Translational …, 2012 - nature.com
Addictions are serious and common psychiatric disorders, and are among the leading
contributors to preventable death. This selective review outlines and highlights the need for …

Endocannabinoid system: chemical characteristics and biological activity

B Rezende, AKN Alencar, GF de Bem… - Pharmaceuticals, 2023 - mdpi.com
The endocannabinoid system (eCB) has been studied to identify the molecular structures
present in Cannabis sativa. eCB consists of cannabinoid receptors, endogenous ligands …

Developmental pathways to adolescent cannabis abuse and dependence: child maltreatment, emerging personality, and internalizing versus externalizing …

A Oshri, FA Rogosch, ML Burnette… - Psychology of addictive …, 2011 - psycnet.apa.org
Child maltreatment is strongly associated with adolescent psychopathology and substance
abuse and dependence. However, developmental processes unfolding from childhood into …

Trajectory of adolescent cannabis use on addiction vulnerability

YL Hurd, M Michaelides, ML Miller, D Jutras-Aswad - Neuropharmacology, 2014 - Elsevier
The adolescent brain is a period of dynamic development making it vulnerable to
environmental factors such as drug exposure. Of the illicit drugs, cannabis is most used by …

Moderators of the association between peer and target adolescent substance use

S Marschall-Lévesque, N Castellanos-Ryan, F Vitaro… - Addictive …, 2014 - Elsevier
Associating with substance using peers is generally considered as one of the most important
predictors of adolescent substance use. However, peer association does not affect all …

Pharmacogenetics of cannabinoids

S Hryhorowicz, M Walczak… - European journal of …, 2018 - Springer
Although the application of medical marijuana and cannabinoid drugs is controversial, it is a
part of modern-day medicine. The list of diseases in which cannabinoids are promoted as a …