Clozapine is known as the firstatypical'medication and is effective in people who have
treatment-resistant schizophrenia. Its 1990 emergence in the USA was marked by …

A systematic approach to the evaluation and characterization of treatment resistance in
schizophrenia has become increasingly important since the introduction of the second …

Clozapine is often referred to as the gold standard for the treatment of schizophrenia and yet
has also been described as the most underutilized treatment for schizophrenia supported by …

Publisher Summary This chapter focuses on amidines and guanidines in medicinal
chemistry. The drugs are classified under their main physiological activities and within each …

A systematic approach to the evaluation and characterization of treatment resistance in
schizophrenia has become increasingly important since the introduction of clozapine …

Background Clozapine is an atypical antipsychotic that is beneficial to some patients who
failed to have an adequate clinical response to other antipsychotic drugs. Its clinical use is …

Introduction The incidence of clozapine-associated myocarditis varies by country. These
variations were explored in VigiBase, the World Health Organization's global database …

Clozapine has been found to be superior to traditional neuroleptics in the treatment of
refractory schizophrenia and is increasingly being used to treat schizophrenia, affective …

Objective To evaluate the efficacy and safety of clozapine for treatment‐resistant bipolar
disorder (TRBD). Methods A systematic review of randomized controlled studies, open‐label …

The authors describe a powerful narrative therapy, one that relies on the wisdom and
everyday language of patients' real-life stories instead of the expert knowledge and …