The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons
M Sharma, P Pal, SK Gupta - Brain Research, 2024 - Elsevier
Alzheimer's Disease (AD) represents a complex interplay of neurological pathways and
molecular mechanisms, with significant impacts on patients' lives. This review synthesizes …
molecular mechanisms, with significant impacts on patients' lives. This review synthesizes …
Matrix disequilibrium in Alzheimer's disease and conditions that increase Alzheimer's disease risk
Alzheimer's Disease (AD) and related dementias are a leading cause of death globally and
are predicted to increase in prevalence. Despite this expected increase in the prevalence of …
are predicted to increase in prevalence. Despite this expected increase in the prevalence of …
Age-Dependent Sex Differences in Perineuronal Nets in an APP Mouse Model of Alzheimer's Disease Are Brain Region-Specific
R Rahmani, N Rambarack, J Singh… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia, which disproportionately
affects women. AD symptoms include progressive memory loss associated with amyloid-β …
affects women. AD symptoms include progressive memory loss associated with amyloid-β …
Depolarization shift in the resting membrane potential of inferior colliculus neurons explains their hyperactivity induced by an acoustic trauma
CJ Hsiao, AV Galazyuk - Frontiers in neuroscience, 2023 - frontiersin.org
Introduction Neuronal hyperactivity has been associated with many brain diseases. In the
auditory system, hyperactivity has been linked to hyperacusis and tinnitus. Previous …
auditory system, hyperactivity has been linked to hyperacusis and tinnitus. Previous …
Age-related upregulation of perineuronal nets on inferior collicular cells that project to the cochlear nucleus
LS Almassri, AP Ohl, MC Iafrate, AD Wade… - Frontiers in Aging …, 2023 - frontiersin.org
Introduction Disruptions to the balance of excitation and inhibition in the inferior colliculus
(IC) occur during aging and underlie various aspects of hearing loss. Specifically, the age …
(IC) occur during aging and underlie various aspects of hearing loss. Specifically, the age …
Linking social cognition, parvalbumin interneurons, and oxytocin in Alzheimer's disease: an update
D Černotová, K Hrůzová, D Levčík… - Journal of …, 2023 - content.iospress.com
Finding a cure for Alzheimer's disease (AD) has been notoriously challenging for many
decades. Therefore, the current focus is mainly on prevention, timely intervention, and …
decades. Therefore, the current focus is mainly on prevention, timely intervention, and …
Decreased extrasynaptic δ‐GABAA receptors in PNN‐associated parvalbumin interneurons correlates with anxiety in APP and tau mouse models of Alzheimer's …
W Zhang, T Liu, J Li, J Singh, A Chan… - British Journal of …, 2024 - Wiley Online Library
Background Alzheimer's disease (AD) is associated with gradual memory loss and anxiety
which affects~ 75% of AD patients. This study investigated whether AD‐associated anxiety …
which affects~ 75% of AD patients. This study investigated whether AD‐associated anxiety …
Advances in Therapeutics to Alleviate Cognitive Decline and Neuropsychiatric Symptoms of Alzheimer's Disease
J Li, A Haj Ebrahimi, AB Ali - International Journal of Molecular Sciences, 2024 - mdpi.com
Dementia exists as a 'progressive clinical syndrome of deteriorating mental function
significant enough to interfere with activities of daily living', with the most prevalent type of …
significant enough to interfere with activities of daily living', with the most prevalent type of …
Hypothalamic and hippocampal transcriptome changes in AppNL-GF mice as a function of metabolic and inflammatory dysfunction
The progression of Alzheimer's disease (AD) has a silent phase that predates characteristic
cognitive decline and eventually leads to active cognitive deficits. Metabolism, diet, and …
cognitive decline and eventually leads to active cognitive deficits. Metabolism, diet, and …
The Pathophysiological Underpinnings of Gamma-Band Alterations in Psychiatric Disorders
Investigating the biophysiological substrates of psychiatric illnesses is of great interest to our
understanding of disorders' etiology, the identification of reliable biomarkers, and potential …
understanding of disorders' etiology, the identification of reliable biomarkers, and potential …