Immunosuppressive drugs in kidney transplantation: impact on patient survival, and incidence of cardiovascular disease, malignancy and infection

R Marcén - Drugs, 2009 - Springer
Renal transplant recipients have increased mortality rates when compared with the general
population. The new immunosuppressive drugs have improved short-term patient survival …

Manifestations of human cytomegalovirus infection: proposed mechanisms of acute and chronic disease

W Britt - Human cytomegalovirus, 2008 - Springer
Infections with human cytomegalovirus (HCMV) are a major cause of morbidity and mortality
in humans with acquired or developmental deficits in innate and adaptive immunity. In the …

Cytomegalovirus reactivation in critically ill immunocompetent patients

AP Limaye, KA Kirby, GD Rubenfeld, WM Leisenring… - Jama, 2008 - jamanetwork.com
Context Cytomegalovirus (CMV) infection is associated with adverse clinical outcomes in
immunosuppressed persons, but the incidence and association of CMV reactivation with …

International consensus guidelines on the management of cytomegalovirus in solid organ transplantation

CN Kotton, D Kumar, AM Caliendo, A Åsberg… - …, 2010 - journals.lww.com
Cytomegalovirus (CMV) remains one of the most common infections after solid organ
transplantation, resulting in significant morbidity, graft loss, and occasional mortality …

Progress and challenges in the prevention, diagnosis, and management of cytomegalovirus infection in transplantation

AP Limaye, TM Babu, M Boeckh - Clinical Microbiology Reviews, 2020 - Am Soc Microbiol
Hosts with compromised or naive immune systems, such as individuals living with HIV/AIDS,
transplant recipients, and fetuses, are at the highest risk for complications from …

[HTML][HTML] Prophylactic versus preemptive oral valganciclovir for the management of cytomegalovirus infection in adult renal transplant recipients

JA Khoury, GA Storch, DL Bohl, RM Schuessler… - American Journal of …, 2006 - Elsevier
Prophylaxis reduces cytomegalovirus (CMV) disease, but is associated with increased costs
and risks for side effects, viral resistance and late onset CMV disease. Preemptive therapy …

[HTML][HTML] Improvement in long-term renal graft survival due to CMV prophylaxis with oral ganciclovir: results of a randomized clinical trial

V Kliem, L Fricke, T Wollbrink, M Burg… - American Journal of …, 2008 - Elsevier
Oral ganciclovir prophylaxis and intravenous preemptive therapy are competitive
approaches to prevent cytomegalovirus (CMV) disease after renal transplantation. This trial …

Delayed-onset primary cytomegalovirus disease and the risk of allograft failure and mortality after kidney transplantation

SK Arthurs, AJ Eid, RA Pedersen… - Clinical infectious …, 2008 - academic.oup.com
Background. During the contemporary era of antiviral prophylaxis, the impact of delayed-
onset primary cytomegalovirus (CMV) disease on the outcome of kidney transplantation is …

[HTML][HTML] The 'indirect'effects of cytomegalovirus infection

RB Freeman Jr - American Journal of Transplantation, 2009 - Elsevier
Cytomegalovirus (CMV) remains the most important infection in the immunocompromized
host even in the era of effective therapy. CMV is usually acquired early in life and can be …

[HTML][HTML] Two-year outcomes in de novo renal transplant recipients receiving everolimus-facilitated calcineurin inhibitor reduction regimen from the TRANSFORM study

SP Berger, C Sommerer, O Witzke, H Tedesco… - American Journal of …, 2019 - Elsevier
TRANSFORM (TRANSplant eFficacy and safety Outcomes with an eveRolimus-based
regiMen) was a 24-month, prospective, open-label trial in 2037 de novo renal transplant …