Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …

Introduction: Naturally occurring compounds play an essential role in the prevention and
treatment of various cancers. There are more than 100 plant and animal based natural …

Cancer stands in the frontline among leading killers worldwide and the annual mortality rate
is expected to reach 16.4 million by 2040. Humans suffer from about 200 different types of …

Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

Coordinated regulation of the lysosomal and autophagic systems ensures basal catabolism
and normal cell physiology, and failure of either system causes disease. Here we describe …

Simple Summary This review discusses current techniques used to study post-translational
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …

Protein acetylation is a reversible post-translational modification, and is involved in many
biological processes in cells, such as transcriptional regulation, DNA damage repair, and …

Tenalisib (RP6530), a dual phosphoinositide 3-kinase δ/γ inhibitor was evaluated in a
phase I/Ib study for maximum tolerated dose (MTD), pharmacokinetics, and efficacy in …

Histone deacetylase 6 (HDAC6) has been targeted in clinical studies for anticancer effects
due to its role in oncogenic transformation and metastasis. Through a second-generation …

Energy band structure of inorganic nano‐sonosensitizers is usually optimized by surface
decoration with noble metals or metal oxide semiconductors, aiming to enhance interfacial …