Abstract The Chromobacterium sp. Panama bacterium has in vivo and in vitro anti-
Plasmodium properties. To assess the nature of the Chromobacterium-produced anti …

The regulation of gene transcription by epigenetic modifications is closely related to many
important life processes and is a hot research topic in the post-genomic era. Since the …

Cancer cells display pervasive changes in DNA methylation, disrupted patterns of histone
posttranslational modification, chromatin composition or organization and regulatory …

Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of three human
malignancies, the endothelial cell cancer Kaposi's sarcoma, and two B cell cancers, Primary …

The proteasome degrades proteins, which is essential for cellular homeostasis. Ubiquitin
independent proteolysis degrades highly disordered and misfolded proteins. A decline of …

The immune system represents the major primary defense line against carcinogenesis and
acts by identifying and eradicating nascent transformed cells. A growing body of evidence is …

Histone deacetylases (HDAC) are epigenetic enzymes responsible for repressing gene
expression through the deacetylation of histone lysine residues. Therefore, inhibition of …

Abnormally high levels of class I histone deacetylases (HDACs) are associated with triple-
negative breast cancer (TNBC) proliferation, malignant transformation, and poor prognosis …

Aberrant expression or dysfunction of cyclin‐dependent kinase 7 (CDK7) and histone
deacetylase 1 (HDAC1) are associated with the occurrence and progression of various …

For many years, antibody drug conjugates (ADC) have teased with the promise of targeted
payload delivery to diseased cells, embracing the targeting of the antibody to which a …