Introduction: Over the past two decades, deeper understanding of B-cell signaling pathways
and other mechanisms of lymphomagenesis have yielded promising targets for novel drugs …

Sézary syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphomas
(CTCL) in which the human Telomerase Reverse Transcriptase (hTERT) gene is re …

Sphingolipids represent one of the major classes of bioactive lipids. Studies of sphingolipids
have intensified in the past several years, revealing their roles in nearly all cell biological …

Due to the increasing prevalence of cancer year by year, and the complexity and refractory
nature of the disease itself, it is required to constantly innovate the development of new …

Reversible lysine acetylation is a major posttranslational modification in histones and
nonhistone proteins. Modulation of this process is an important target for drug discovery …

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare subtype of cutaneous T-
cell lymphoma that usually presents with tender subcutaneous nodules on the trunk and …

Romidepsin is a cyclic peptide derived from a natural product that has shown remarkable
therapeutic potential for the treatment of cancer and other diseases. In this study, we employ …

[ES] En las últimas décadas se han aportado múltiples evidencias que demuestran que el
cáncer no es sólo una enfermedad de carácter genético, sino que los mecanismos …

Humane endogene Retroviren (HERVs) wurden während der Evolution durch Infektionen
mit exogenen Retroviren in unser Genom integriert. Eine Vielzahl dieser Elemente wird …

The term epigenetics dates back to the 1940s, when Conrad Waddington introduced it to
refer to gene expression changes that occur during development and do not involve …