Inflammatory cardiomyopathy, characterized by inflammatory cell infiltration into the
myocardium and a high risk of deteriorating cardiac function, has a heterogeneous …

In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …

B cells are essential components of the adaptive immune system and have important roles
in the pathogenesis of several central nervous system (CNS) diseases. Besides producing …

There is growing recognition that B cell contributions to normal immune responses extend
well beyond their potential to become antibody-producing cells, including roles at the innate …

Myocarditis is generally a mild and self-limited consequence of systemic infection of
cardiotropic viruses. However, patients can develop a temporary or permanent impairment …

B lymphocytes have critical roles as positive and negative regulators of immunity. Their
inhibitory function has been associated primarily with interleukin 10 (IL-10) because B-cell …

Monoclonal antibodies that target CD20 expressing B cells represent an important new
treatment option for patients with multiple sclerosis (MS). B‐cell‐depleting therapy is highly …

While no single model can exactly recapitulate all aspects of multiple sclerosis (MS), animal
models are essential in understanding the induction and pathogenesis of the disease and to …