Chitosan-palmitic acid based polymeric micelles as promising carrier for circumventing pharmacokinetic and drug delivery concerns of tamoxifen
Being a BCS class II drug and a good substrate for microsomal enzymes, tamoxifen (TAM)
offers a scope for research owing to poor aqueous solubility and compromised …
offers a scope for research owing to poor aqueous solubility and compromised …
Exploration of docetaxel palmitate and its solid lipid nanoparticles as a novel option for alleviating the rising concern of multi-drug resistance
L Kaushik, S Srivastava, A Panjeta, D Chaudhari… - International Journal of …, 2020 - Elsevier
Docetaxel (DTX), a widely prescribed anticancer agent, is now associated with increased
instances of multidrug resistance. Also, being a problematic BCS class IV drug, it poses …
instances of multidrug resistance. Also, being a problematic BCS class IV drug, it poses …
Chrysin and docetaxel loaded biodegradable micelle for combination chemotherapy of cancer stem cell
A Ghamkhari, A Pouyafar, R Salehi… - Pharmaceutical …, 2019 - Springer
Abstract Purpose Cancer stem cells (CSCs) have been suggested to represent the main
cause of tumour progression, metastasis and drug resistance. Therefore, these cells can be …
cause of tumour progression, metastasis and drug resistance. Therefore, these cells can be …
Conjugated and entrapped HPMA-PLA nano-polymeric micelles based dual delivery of first line anti TB drugs: improved and safe drug delivery against sensitive and …
Purpose First line antiTB drugs have several physical and toxic manifestations which limit
their applications. RIF is a hydrophobic drug and has low water solubility and INH is …
their applications. RIF is a hydrophobic drug and has low water solubility and INH is …
In vivo pharmacokinetic studies and intracellular delivery of methotrexate by means of glycine-tethered PLGA-based polymeric micelles
Methotrexate (MTX) is a widely used drug for the management of various kinds of cancers.
However, numerous challenges are associated with MTX like poor aqueous solubility, dose …
However, numerous challenges are associated with MTX like poor aqueous solubility, dose …
Aspartic acid derivatized hydroxylated fullerenes as drug delivery vehicles for docetaxel: An explorative study
The objective of the present study was to deliver docetaxel to cancerous cells with enhanced
efficacy and safety profile, using aspartic acid linked fullerenols. This aspartic acid …
efficacy and safety profile, using aspartic acid linked fullerenols. This aspartic acid …
Role of colloidal drug delivery carriers in taxane-mediated chemotherapy: a review
Chemotherapy is one of the most frequently employed and reliable treatment options for the
management of a variety of cancers. Taxanes (paclitaxel, docetaxel and cabazitaxel) are …
management of a variety of cancers. Taxanes (paclitaxel, docetaxel and cabazitaxel) are …
Polysaccharide dextran-based conjugate for selective co-delivery of two synergistic drugs docetaxel and docosahexaenoic acid to tumor cells
P Dong, H Lv, W Jia, J Liu, S Wang, X Li, J Hu… - Drug …, 2023 - Taylor & Francis
Most chemotherapeutic agents are nonspecific distribution and cause systemic toxicities.
Polysaccharide-based conjugates are promising strategies to overcome these drawbacks …
Polysaccharide-based conjugates are promising strategies to overcome these drawbacks …
Photoinduced Mild Hyperthermia and Synergistic Chemotherapy by One-Pot-Synthesized Docetaxel-Loaded Poly(lactic-co-glycolic acid)/Polypyrrole …
Mild hyperthermia has shown great advantages when combined with chemotherapy. The
development of a multifunctional platform for the integration of mild hyperthermia capability …
development of a multifunctional platform for the integration of mild hyperthermia capability …
Delivery of docetaxel to brain employing piperine-tagged PLGA-aspartic acid polymeric micelles: improved cytotoxic and pharmacokinetic profiles
A Singh, N Thotakura, B Singh, S Lohan, P Negi… - AAPS …, 2019 - Springer
In this study, poly-(lactic-co-glycolic) acid (PLGA) was conjugated with aspartic acid and was
characterized by nuclear magnetic resonance and Fourier transform infrared spectroscopy …
characterized by nuclear magnetic resonance and Fourier transform infrared spectroscopy …