The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades
of biochemistry and genetics combined with recent structural studies of the spliceosome …

Precursor messenger RNA (pre-mRNA) splicing is an essential step in the flow of
information from DNA to protein in all eukaryotes. Research over the past four decades has …

Recent events have pushed RNA research into the spotlight. Continued discoveries of RNA
with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as …

Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscriptional
regulation of gene expression, providing significant expansion of the functional proteome of …

Intron removal requires assembly of the spliceosome on precursor mRNA (pre-mRNA) and
extensive remodelling to form the spliceosome's catalytic centre. Here we report the cryo …

The spliceosome, one of the most complex machineries of eukaryotic cells, removes intronic
sequences from primary transcripts to generate functional messenger and long noncoding …

Spliceosome rearrangements facilitated by RNA helicase PRP16 before catalytic step two of
splicing are poorly understood. Here we report a 3D cryo-electron microscopy structure of …

The spliceosome is a highly complex, dynamic ribonucleoprotein molecular machine that
undergoes numerous structural and compositional rearrangements that lead to the formation …

The spliceosome is a highly dynamic macromolecular complex that precisely excises introns
from pre-mRNA. Here we report the cryo-EM 3D structure of the human B act spliceosome at …

Precursor mRNA (pre-mRNA) splicing proceeds by two consecutive transesterification
reactions via a lariat–intron intermediate. Here we present the 3.8 Å cryo-electron …