Modulation of intracellular copper levels as the mechanism of action of anticancer copper complexes: Clinical relevance
Copper (Cu) is a vital element required for cellular growth and development; however, even
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …
[HTML][HTML] Cuproptosis: a novel therapeutic target for overcoming cancer drug resistance
Y Wang, Y Chen, J Zhang, Y Yang, JS Fleishman… - Drug Resistance …, 2023 - Elsevier
Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of
copper and copper triggered cell death in the pathogenesis of cancers have attracted …
copper and copper triggered cell death in the pathogenesis of cancers have attracted …
Antifungal activity of thiosemicarbazones, bis (thiosemicarbazones), and their metal complexes
Fungi are ubiquitous in nature, and typically cause little or no environmental or pathogenic
damage to their plant, animal, and human hosts. However, a small but growing number of …
damage to their plant, animal, and human hosts. However, a small but growing number of …
Ribonucleotide reductases: structure, chemistry, and metabolism suggest new therapeutic targets
Ribonucleotide reductases (RNRs) catalyze the de novo conversion of nucleotides to
deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing …
deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing …
Transition metal chelators, pro-chelators, and ionophores as small molecule cancer chemotherapeutic agents
A Steinbrueck, AC Sedgwick, JT Brewster… - Chemical Society …, 2020 - pubs.rsc.org
Cancer is among the leading causes of death worldwide. Although a number of new
treatment options have been developed in recent years, there remains a need for improved …
treatment options have been developed in recent years, there remains a need for improved …
Iron and chelation in biochemistry and medicine: new approaches to controlling iron metabolism and treating related diseases
GJ Kontoghiorghes, CN Kontoghiorghe - Cells, 2020 - mdpi.com
Iron is essential for all living organisms. Many iron-containing proteins and metabolic
pathways play a key role in almost all cellular and physiological functions. The diversity of …
pathways play a key role in almost all cellular and physiological functions. The diversity of …
[HTML][HTML] Metal-and metalloid-based compounds to target and reverse cancer multidrug resistance
Drug resistance remains the major cause of cancer treatment failure especially at the late
stage of the disease. However, based on their versatile chemistry, metal and metalloid …
stage of the disease. However, based on their versatile chemistry, metal and metalloid …
Redox interactions of vitamin C and iron: Inhibition of the pro-oxidant activity by deferiprone
VA Timoshnikov, TV Kobzeva, NE Polyakov… - International journal of …, 2020 - mdpi.com
Ascorbic acid (AscH2) is one of the most important vitamins found in the human diet, with
many biological functions including antioxidant, chelating, and coenzyme activities. Ascorbic …
many biological functions including antioxidant, chelating, and coenzyme activities. Ascorbic …
Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …
Copper-catalyzed glutathione oxidation is accelerated by the anticancer thiosemicarbazone Dp44mT and further boosted at lower pH
E Falcone, AG Ritacca, S Hager… - Journal of the …, 2022 - ACS Publications
Glutathione (GSH) is the most abundant thiol in mammalian cells and plays a crucial role in
maintaining redox cellular homeostasis. The thiols of two GSH molecules can be oxidized to …
maintaining redox cellular homeostasis. The thiols of two GSH molecules can be oxidized to …