Nearly all genetic variants that influence disease risk have human-specific origins; however,
the systems they influence have ancient roots that often trace back to evolutionary events …

The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

During osmotic changes of their environment, cells actively regulate their volume and
plasma membrane tension that can passively change through osmosis. How tension and …

A fundamental impediment to understanding the brain is the availability of inexpensive and
robust methods for targeting and manipulating specific neuronal populations. The need to …

Curving biological membranes establishes the complex architecture of the cell and mediates
membrane traffic to control flux through subcellular compartments. Common molecular …

Gram-negative bacteria produce outer membrane vesicles (OMVs) that contain biologically
active proteins and perform diverse biological processes. Unlike other secretion …

Copy number variants affect both disease and normal phenotypic variation, but those lying
within heavily duplicated, highly identical sequence have been difficult to assay. By …

The endosomal sorting complexes required for transport (ESCRT) pathway mediates
cellular membrane remodeling and fission reactions. The pathway comprises five core …

The cerebral cortex is at the core of brain functions that are thought to be particularly
developed in the human species. Human cortex specificities stem from divergent features of …

Structural genomic variations represent a major driving force of evolution, and a burst of
large segmental gene duplications occurred in the human lineage during its separation from …