[HTML][HTML] Understanding the role of interleukin-6 (IL-6) in the joint and beyond: a comprehensive review of IL-6 inhibition for the management of rheumatoid arthritis

EG Favalli - Rheumatology and therapy, 2020 - Springer
Rheumatoid arthritis (RA) is a chronic, debilitating autoimmune disorder involving
inflammation and progressive destruction of the joints, affecting up to 1% of the population …

Tocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection

M Biggioggero, C Crotti, A Becciolini… - Drug design …, 2018 - Taylor & Francis
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by articular and
systemic manifestations, such as anemia, fatigue, osteoporosis, and increased risk for …

[HTML][HTML] The second decade of anti-TNF-a therapy in clinical practice: New lessons and future directions in the COVID-19 era

G Evangelatos, G Bamias, GD Kitas, G Kollias… - Rheumatology …, 2022 - Springer
Since the late 1990s, tumor necrosis factor alpha (TNF-α) inhibitors (anti-TNFs) have
revolutionized the therapy of immune-mediated inflammatory diseases (IMIDs) affecting the …

[HTML][HTML] Upadacitinib and filgotinib: the role of JAK1 selective inhibition in the treatment of rheumatoid arthritis

M Biggioggero, A Becciolini, C Crotti, E Agape… - Drugs in …, 2019 - ncbi.nlm.nih.gov
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by
joint involvement, extra-articular manifestations, comorbidities, and increased mortality. In …

Osteoimmunological insights into the pathogenesis of ankylosing spondylitis

L Liu, Y Yuan, S Zhang, J Xu… - Journal of Cellular …, 2021 - Wiley Online Library
Ankylosing spondylitis (AS) is inflammatory arthritis predominantly affecting the spine, which
is involved in the disorders of both immune and skeletal systems. The exact pathogenesis of …

[HTML][HTML] Paradoxical skin reactions to biologics in patients with rheumatologic disorders

S Garcovich, C De Simone, G Genovese… - Frontiers in …, 2019 - frontiersin.org
Targeted immune-modulating treatment with biological agents has revolutionized the
management of immune-mediated inflammatory diseases, including rheumatologic …

Targeting granulocyte-monocyte colony-stimulating factor signaling in rheumatoid arthritis: future prospects

C Crotti, E Agape, A Becciolini, M Biggioggero… - Drugs, 2019 - Springer
Rheumatoid arthritis (RA) is a systemic, autoimmune disease that affects joints and extra-
articular structures. In the last decade, the management of this chronic disease has …

[PDF][PDF] One year in review 2017: novelties in the treatment of rheumatoid arthritis

F Ferro, E Elefante, N Luciano, R Talarico… - Clin Exp …, 2017 - clinexprheumatol.org
Rheumatoid arthritis (RA) is a chronic disease characterised by inflammation of the synovial
tissue in joints, which can lead to joint destruction. The primary goal of the treatment is to …

[HTML][HTML] Switching between biological treatments in psoriatic arthritis: a review of the evidence

L Costa, C Perricone, MS Chimenti, A Del Puente… - Drugs in R&D, 2017 - Springer
Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy. Therapy with anti-tumor
necrosis factor (TNF)-α agents represents the first therapeutic choice for moderate and …

[HTML][HTML] Sperm DNA methylation epimutation biomarkers for male infertility and FSH therapeutic responsiveness

S Luján, E Caroppo, C Niederberger, JC Arce… - Scientific reports, 2019 - nature.com
Male factor infertility is increasing and recognized as playing a key role in reproductive
health and disease. The current primary diagnostic approach is to assess sperm quality …