The human gastrointestinal tract is home to trillions of microbes. Gut microbial communities
have a significant regulatory role in the intestinal physiology, such as gut motility. Microbial …

The increasing prevalence of colonic diseases calls for a better understanding of the various
colonic drug absorption barriers of colon-targeted formulations, and for reliable in vitro tools …

The performance of solid oral dosage forms targeting the colon is typically evaluated using
standardised pharmacopeial dissolution apparatuses. However, these fail to replicate …

The performance of colon-targeted solid dosage forms is commonly assessed using
standardised pharmacopeial dissolution apparatuses like the USP II or the miniaturised …

Small intestine motility and its ensuing flow of luminal content impact both nutrient
absorption and bacterial growth. To explore this interdependence we introduce a …

This paper demonstrates the use of peridynamics and discrete multiphysics to assess micro
crack formation and propagation in asphalt at low temperatures and under freezing …

This micro-article introduces a method for integrating Large Language Models with
geometry/mesh generation software and multiphysics solvers, aimed at streamlining physics …

Knowledge of luminal flow inside the human colon remains elusive, despite its importance
for the design of new colon-targeted drug delivery systems and physiologically relevant in …

Stenting is a common method for treating atherosclerosis. A metal or polymer stent is
deployed to open the stenosed artery or vein. After the stent is deployed, the blood flow …

For colonic drug delivery, the ascending part of the colon is the most favourable site as it
offers the most suitable environmental conditions for drug dissolution. Commonly, the …