[HTML][HTML] Advances in glycoside and oligosaccharide synthesis

CJ Crawford, PH Seeberger - Chemical Society Reviews, 2023 - pubs.rsc.org
The structural complexity of glycans poses a serious challenge in the chemical synthesis of
glycosides, oligosaccharides and glycoconjugates. Glycan complexity, determined by …

Development in the concept of bacterial polysaccharide repeating unit-based antibacterial conjugate vaccines

R Rohokale, Z Guo - ACS infectious diseases, 2023 - ACS Publications
The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx.
The complex glycans in the glycocalyx are involved in various biological events, such as …

Recent chemical synthesis and immunological evaluation of glycans related to bacterial lipopolysaccharides

C Qin, G Tian, J Hu, X Zou, J Yin - Current Opinion in Chemical Biology, 2024 - Elsevier
O-Antigens and core oligosaccharides from bacterial lipopolysaccharides (LPS) are often
structurally unique and immunologically active, have become attractive targets in the …

[HTML][HTML] Effect of side-chain functional groups in the immunogenicity of bacterial surface glycans

G Tian, C Qin, J Hu, X Zou, J Yin - Molecules, 2023 - mdpi.com
Glycans on the surface of bacteria have diverse and essential biological functions and have
widely been employed for treating various bacterial infectious diseases. Furthermore, these …

Chemical Synthesis and Antigenicity Evaluation of an Aminoglycoside Trisaccharide Repeating Unit of Pseudomonas aeruginosa Serotype O5 O-Antigen Containing a Rare …

G Tian, J Hu, C Qin, L Li, Y Ning, S Zhu… - Journal of the …, 2024 - ACS Publications
Pseudomonas aeruginosa bacteria are becoming increasingly resistant against multiple
antibiotics. Therefore, the development of vaccines to prevent infections with these bacteria …

Immunological Exploration of Helicobacter pylori Serotype O2 O‐Antigen by Using a Synthetic Glycan Library

M Zhao, G Tian, C Qin, X Zou… - Chinese Journal of …, 2024 - Wiley Online Library
Comprehensive Summary Helicobacter pylori (H. pylori) infection is a threat to human
health. The lipopolysaccharide (LPS) O‐antigen holds promise for developing vaccines. It is …

[HTML][HTML] NMR chemical shift prediction and structural elucidation of linker-containing oligo-and polysaccharides using the computer program CASPER

KM Dorst, G Widmalm - Carbohydrate research, 2023 - Elsevier
Carbohydrate structures containing alkyl groups as aglycones are useful for investigating
enzyme activity and glycan-protein interactions. Moreover, linker-containing …

Chemical Synthesis of a Key Precursor Relevant to the Tetrasaccharide Repeating Unit from Treponema medium ATCC 700293

W Sun, G Tian, M Ding, C Qin, X Zou… - Chinese Journal of …, 2024 - Wiley Online Library
Comprehensive Summary Treponema is a Gram‐negative anaerobic bacterium, among
which the pathogenic Treponema can cause various diseases, such as venereal syphilis …

Expeditious Synthesis of Gwanakoside A and the Chloronaphthol Glycoside Congeners

Y Cheng, Y Xia, Z Yuan, H Li, J Wang, Y Wang… - Organic …, 2024 - ACS Publications
The synthesis of gwanakoside A, a chlorinated naphthol bis-glycoside, and its analogues
was achieved through stepwise chlorination and donor-equivalent controlled regioselective …

[HTML][HTML] A universal UHPLC-CAD platform for the quantification of polysaccharide antigens

A Corrado, M De Martino, V Bordoni, S Giannini… - Scientific Reports, 2023 - nature.com
Several glycoconjugate-based vaccines against bacterial infections have been developed
and licensed for human use. Polysaccharide (PS) analysis and characterization is therefore …