In order to be approved for marketing in the United States, drugs must be proven to be safe
and effective using “adequate and well‐controlled investigations.” This chapter clarifies the …

The leading reference in reproductive health for 30 years, with over 2,000,000 copies in
print, Contraceptive Technology is included on CD-ROM with all copies of the book and also …

Objective To assess the risk of venous thrombosis in current users of non-oral hormonal
contraception. Design Historical national registry based cohort study. Setting Four national …

THE LANCET• Vol 363• May 22, 2004• www. thelancet. com 1729 based on expected
prognosis, with the intention to change a disease outcome. Judgment of a patient's …

Objectives To evaluate the risk of venous thromboembolic events associated with the use of
progestin-only contraception and whether that risk differs with the mode of drug delivery …

In the early 1960s, shortly after the introduction of oral contraceptives, the first case reports
appeared describing venous thrombosis and pulmonary emboli in women using this method …

OBJECTIVES: The study was conducted to compare risks of adverse cardiovascular and
other events associated with the use of drospirenone (DRSP)-containing oral contraceptives …

Venous thrombosis occurs in about 1 per 1,000 individuals per year. 1, 2 It usually affects
the deep veins of the leg, but may occur in other sites, such as the upper extremities …

The United Kingdom General Practice Research Database (GPRD) is an office‐based,
computer‐generated, medical resource designed from its inception to be used for …

ContextThe relationship between ischemic stroke and oral contraceptive (OC) use has been
studied for 40 years, but disagreement about an association persists. ObjectiveTo review …