Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

The aging process results in significant epigenetic changes at all levels of chromatin and
DNA organization. These include reduced global heterochromatin, nucleosome remodeling …

Aging causes a functional decline in tissues throughout the body that may be delayed by
caloric restriction (CR). However, the cellular profiles and signatures of aging, as well as …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Background Dietary restriction (DR), a reduction in food intake without malnutrition,
increases most aspects of health during aging and extends lifespan in diverse species …

Introduction: Aging is a normal, inevitable, irreversible and progressive process which is
driven by internal and external factors. Oxidative stress, that is the imbalance between …

Calorie restriction (CR) increases lifespan and improves brain health in mice. Ad libitum low-
protein, high-carbohydrate (LPHC) diets also extend lifespan, but it is not known whether …

Dietary restriction (DR) has long been viewed as the most robust nongenetic means to
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …

Histone modifications are key epigenetic regulators that control chromatin structure and
gene transcription, thereby impacting on various important cellular phenotypes. Over the …

Aging is characterized by an extensive remodeling of epigenetic patterns, which has been
implicated in the physiopathology of age-related diseases. Nutrition plays a significant role …