Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer

WM Grady - Advances in cancer research, 2021 - Elsevier
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

How to stomach an epigenetic insult: the gastric cancer epigenome

N Padmanabhan, T Ushijima, P Tan - Nature reviews Gastroenterology …, 2017 - nature.com
Gastric cancer is a deadly malignancy afflicting close to a million people worldwide. Patient
survival is poor and largely due to late diagnosis and suboptimal therapies. Disease …

Epigenetic mechanisms of aging and aging-associated diseases

A la Torre, F Lo Vecchio, A Greco - Cells, 2023 - mdpi.com
Aging is an inevitable outcome of life, characterized by a progressive decline in tissue and
organ function. At a molecular level, it is marked by the gradual alterations of biomolecules …

Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer

MH Kang, H Choi, M Oshima, JH Cheong, S Kim… - Nature …, 2018 - nature.com
The principle factors underlying gastric cancer (GC) development and outcomes are not well
characterized resulting in a paucity of validated therapeutic targets. To identify potential …

Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis

AKH Loe, L Zhu, TH Kim - Experimental & molecular medicine, 2023 - nature.com
Gastric cancer (GC) is one of the most common and deadly cancers in the world. It is a
multifactorial disease highly influenced by environmental factors, which include radiation …

ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma

T Li, L Xu, Z Wei, S Zhang, X Liu, Y Yang, Y Gu… - Molecular cancer, 2023 - Springer
Background Renal cell carcinoma (RCC) is a common malignant tumor of the urinary
system. Angiogenesis is a main contributing factor for tumorigenesis. E74-like transcription …

Epigenetic mechanisms in gastric cancer: potential new therapeutic opportunities

M Canale, A Casadei-Gardini, P Ulivi… - International Journal of …, 2020 - mdpi.com
Gastric cancer (GC) is one of the deadliest malignancies worldwide. Complex disease
heterogeneity, late diagnosis, and suboptimal therapies result in the poor prognosis of …

DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells

W Sun, G Ma, L Zhang, P Wang, N Zhang, Z Wu… - Cell Death & …, 2021 - nature.com
ADAMTS9 belongs to the ADAMTS (a disintegrin and metalloproteinase with
thrombospondin motifs) protein family, and its expression is frequently silenced due to …

[HTML][HTML] Follow-up after curative resection for gastric cancer: Is it time to tailor it?

P Aurello, N Petrucciani, L Antolino… - World Journal of …, 2017 - ncbi.nlm.nih.gov
There is still no consensus on the follow-up frequency and regimen after curative resection
for gastric cancer. Moreover, controversy exists regarding the utility of follow-up in improving …

A four-DNA methylation signature as a novel prognostic biomarker for survival of patients with gastric cancer

C Li, Y Zheng, K Pu, D Zhao, Y Wang, Q Guan… - Cancer Cell …, 2020 - Springer
Background Gastric cancer (GC) is the fifth most frequently diagnosed cancer and the third
leading cause of cancer-related mortality. Lack of prognostic indicators for patient survival …