[HTML][HTML] The hypothalamic-pituitary-adrenal axis: development, programming actions of hormones, and maternal-fetal interactions
The hypothalamic-pituitary adrenal axis is a complex system of neuroendocrine pathways
and feedback loops that function to maintain physiological homeostasis. Abnormal …
and feedback loops that function to maintain physiological homeostasis. Abnormal …
Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms
This paper reviews the research evidence concerning the intergenerational transmission of
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …
Zinc as a gatekeeper of immune function
I Wessels, M Maywald, L Rink - Nutrients, 2017 - mdpi.com
After the discovery of zinc deficiency in the 1960s, it soon became clear that zinc is essential
for the function of the immune system. Zinc ions are involved in regulating intracellular …
for the function of the immune system. Zinc ions are involved in regulating intracellular …
Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure
M Van Bodegom, JR Homberg… - Frontiers in cellular …, 2017 - frontiersin.org
Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …
consequences, increasing overall risk on psychopathology. One of the key stress response …
Understanding resilience
Resilience is the ability to adapt successfully in the face of stress and adversity. Stressful life
events, trauma, and chronic adversity can have a substantial impact on brain function and …
events, trauma, and chronic adversity can have a substantial impact on brain function and …
Biological embedding of experience: a primer on epigenetics
MJ Aristizabal, I Anreiter… - Proceedings of the …, 2020 - National Acad Sciences
Biological embedding occurs when life experience alters biological processes to affect later
life health and well-being. Although extensive correlative data exist supporting the notion …
life health and well-being. Although extensive correlative data exist supporting the notion …
The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome
Stressful experiences during early-life can modulate the genetic programming of specific
brain circuits underlying emotional and cognitive aspects of behavioral adaptation to …
brain circuits underlying emotional and cognitive aspects of behavioral adaptation to …
Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene–environment interactions, and epigenetics
Early life stress, such as childhood abuse, neglect and loss, is a well established major risk
factor for developing depressive disorders later in life. We here summarize and discuss …
factor for developing depressive disorders later in life. We here summarize and discuss …
Epigenetics of stress-related psychiatric disorders and gene× environment interactions
A deeper understanding of the pathomechanisms leading to stress-related psychiatric
disorders is important for the development of more efficient preventive and therapeutic …
disorders is important for the development of more efficient preventive and therapeutic …
Epigenetic basis of mental illness
Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function as well as likely abnormalities in glial cells. While …
neural circuit structure and function as well as likely abnormalities in glial cells. While …