[HTML][HTML] Role of CFTR in epithelial physiology
V Saint-Criq, MA Gray - Cellular and Molecular Life Sciences, 2017 - Springer
Salt and fluid absorption and secretion are two processes that are fundamental to epithelial
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …
The SLC26 gene family of anion transporters and channels
The phylogenetically ancient SLC26 gene family encodes multifunctional anion exchangers
and anion channels transporting a broad range of substrates, including Cl−, HCO3−, sulfate …
and anion channels transporting a broad range of substrates, including Cl−, HCO3−, sulfate …
The SLC4 family of bicarbonate (HCO3-) transporters
The SLC4 family consists of 10 genes (SLC4A1–5; SLC4A7–11). All encode integral
membrane proteins with very similar hydropathy plots—consistent with 10–14 …
membrane proteins with very similar hydropathy plots—consistent with 10–14 …
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters
MD Parker, WF Boron - Physiological reviews, 2013 - journals.physiology.org
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
Physiology of epithelial chloride and fluid secretion
RA Frizzell, JW Hanrahan - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Epithelial salt and water secretion serves a variety of functions in different organ systems,
such as the airways, intestines, pancreas, and salivary glands. In cystic fibrosis (CF), the …
such as the airways, intestines, pancreas, and salivary glands. In cystic fibrosis (CF), the …
The cystic fibrosis of exocrine pancreas
M Wilschanski, I Novak - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
The cystic fibrosis transmembrane conductance regulator (CFTR) protein is highly
expressed in the pancreatic duct epithelia and permits anions and water to enter the ductal …
expressed in the pancreatic duct epithelia and permits anions and water to enter the ductal …
The solute carrier 26 family of proteins in epithelial ion transport
MR Dorwart, N Shcheynikov, D Yang… - Physiology, 2008 - journals.physiology.org
Transepithelial Cl− and HCO3− transport is critically important for the function of all epithelia
and, when altered or ablated, leads to a number of diseases, including cystic fibrosis …
and, when altered or ablated, leads to a number of diseases, including cystic fibrosis …
Regulation of electroneutral NaCl absorption by the small intestine
Na+ and Cl− movement across the intestinal epithelium occurs by several interconnected
mechanisms:(a) nutrient-coupled Na+ absorption,(b) electroneutral NaCl absorption,(c) …
mechanisms:(a) nutrient-coupled Na+ absorption,(b) electroneutral NaCl absorption,(c) …
The physiology and pathophysiology of pancreatic ductal secretion: the background for clinicians
The human exocrine pancreas consists of 2 main cell types: acinar and ductal cells. These
exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most …
exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most …
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3− secretion: relevance to cystic fibrosis
Y Wang, AA Soyombo, N Shcheynikov, W Zeng… - The EMBO …, 2006 - embopress.org
Fluid and HCO3− secretion are vital functions of the pancreatic duct and other secretory
epithelia. CFTR and Cl−/HCO3− exchange activity at the luminal membrane are required for …
epithelia. CFTR and Cl−/HCO3− exchange activity at the luminal membrane are required for …