Three-dimensional protein structure is directly correlated with its function and its
determination is critical to understanding biological processes and addressing human …

Engineered thermostable microbial enzymes are widely employed to catalyze chemical
reactions in numerous industrial sectors. Although high thermostability is a prerequisite of …

The continued evolution of SARS-CoV-2 has led to the emergence of several new Omicron
subvariants, including BQ. 1, BQ. 1.1, BA. 4.6, BF. 7, and BA. 2.75. 2. Here, we examine the …

Deep-learning methods have revolutionized protein structure prediction and design but are
presently limited to protein-only systems. We describe RoseTTAFold All-Atom (RFAA), which …

Omicron subvariants continuingly challenge current vaccination strategies. Here, we
demonstrate nearly complete escape of the XBB. 1.5, CH. 1.1, and CA. 3.1 variants from …

Summary The newly emerged BA. 2.75 severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) variant contains 9 additional mutations in its spike (S) protein compared to …

Tonic signaling of chimeric antigen receptor (CAR), ie, the spontaneous CAR activation in
the absence of tumor antigen stimulation, is considered to be a pivotal event controlling CAR …

Abstract Angiotensin converting enzyme 2 (ACE2)(EC: 3.4. 17.23) is a transmembrane
protein which is considered as a receptor for spike protein binding of novel coronavirus …

Protein complexes of the mitochondrial respiratory chain assemble into respiratory
supercomplexes. Here we present the high-resolution electron cryo-microscopy structure of …

Sarcomeres are force-generating and load-bearing devices of muscles. A precise molecular
picture of how sarcomeres are built underpins understanding their role in health and …