Background: The ability to predict transfusion requirements may improve perioperative
bleeding management as an integral part of a patient blood management program …

The early and aggressive high-volume administration of fresh frozen plasma, platelet
concentrates, and red blood cells (RBCs), using ratio-driven massive transfusion protocols …

Trauma is a leading cause of death worldwide in persons under 44 years of age, and
uncontrolled haemorrhage is the most common preventable cause of death in this patient …

Shock is the inability of the body to maintain adequate end-organ perfusion. Hypovolemic
shock caused by blood loss is frequently encountered after severe injury. 1 Hemorrhagic …

BACKGROUND Despite poor evidence and high costs, fibrinogen concentrate (FC)
represents one of the most frequently used hemostatic agents in exsanguinating trauma …

Introduction The diagnostic potential of whole blood viscoelastic tests thromboelastography
(TEG®) and thromboelastometry (ROTEM®) to detect warfarin-induced INR elevation …

BACKGROUND The use of massive transfusion protocols (MTPs) in the resuscitation of
hemorrhaging trauma patients ensures rapid delivery of blood products to improve …

Background Fibrinogen concentrate (FC) is increasingly used as first line therapy in
bleeding trauma patients. It remains unproven whether FC application increases post …

Background Identifying hypofibrinogenemia in trauma is important. The optimal method of
fibrinogen determination is unknown. We therefore evaluated fibrinogen levels determined …

Background While much effort has been spent on guiding coagulation and transfusion
therapy in patients undergoing cardiopulmonary bypass (CPB) surgery, the use of …