Matrix metalloproteinases (MMPs), a group of zinc-dependent endopeptidases involved in
the degradation of the extracellular matrix, play an important role in tissue remodeling …

Throughout history, humankind has won the battle against deadly diseases, including small
pox and polio, by defeating them through prevention. Cancer prevention is a global priority …

Purpose Prostate growth and differentiation are under androgenic control, and prior studies
suggested that tumors that develop in hypogonadal men are more aggressive. We …

Purpose: The PCPT has demonstrated a higher incidence of high grade (Gleason pattern 4
or greater) prostate cancers among men randomized to finasteride. One plausible …

Abstract Background The Prostate Cancer Prevention Trial (PCPT) demonstrated a 24.8%
reduction in the 7-year prevalence of prostate cancer among patients treated with finasteride …

PURPOSE: A recent prostate cancer finasteride chemoprevention trial showed a higher rate
of sextant biopsy-detected high grade prostate cancer (HGPCa) in finasteride exposed men …

High-grade prostate cancers express high levels of matrix metalloproteinases (MMPs),
major enzymes involved in tumor invasion and metastasis. However, the tumor cell lines …

Results of a population-based, randomized phase III trial demonstrates that finasteride can
prevent prostate cancer. A large amount of data supports the use of other agents as potential …

Benefit-risk assessment is at the centre of the approval process for every new medicine. The
ability to assess the risks of a new medicine accurately and to balance these against the …

Introduction The use of the 5-alpha reductase inhibitors (5-ARIs) finasteride and dutasteride
for prostate cancer prevention is still under debate. The FDA recently concluded that the …