Translation of cell therapies to treat autoimmune disorders
Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial
impact on patient quality of life and a significant global healthcare burden. Current …
impact on patient quality of life and a significant global healthcare burden. Current …
[HTML][HTML] Wharton's jelly mesenchymal stem cells: a concise review of their secretome and prospective clinical applications
Accumulating evidence indicates that most primary Wharton's jelly mesenchymal stem cells
(WJ-MSCs) therapeutic potential is due to their paracrine activity, ie, their ability to modulate …
(WJ-MSCs) therapeutic potential is due to their paracrine activity, ie, their ability to modulate …
[HTML][HTML] Current status of stem cell therapy for type 1 diabetes: a critique and a prospective consideration
MA Ghoneim, MM Gabr, SM El-Halawani… - Stem Cell Research & …, 2024 - Springer
Over the past decade, there had been progress in the development of cell therapy for insulin-
dependent diabetes. Nevertheless, important hurdles that need to be overcome still remain …
dependent diabetes. Nevertheless, important hurdles that need to be overcome still remain …
Clinical Application of Umbilical Cord Mesenchymal Stem Cells Preserves β-cells in Type 1 Diabetes
A Al Madhoun, L Koti, N Carrió, M Atari… - Stem Cells …, 2024 - academic.oup.com
Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease associated with
complications that reduce the quality of life of affected individuals and their families. The …
complications that reduce the quality of life of affected individuals and their families. The …
[HTML][HTML] A Supportive Role of Mesenchymal Stem Cells on Insulin-Producing Langerhans Islets with a Specific Emphasis on The Secretome
RV Sionov, R Ahdut-HaCohen - Biomedicines, 2023 - mdpi.com
Type 1 Diabetes (T1D) is a chronic autoimmune disease characterized by a gradual
destruction of insulin-producing β-cells in the endocrine pancreas due to innate and specific …
destruction of insulin-producing β-cells in the endocrine pancreas due to innate and specific …
[HTML][HTML] Novel lipid mediator 7S,14R-docosahexaenoic acid: biogenesis and harnessing mesenchymal stem cells to ameliorate diabetic mellitus and retinal pericyte …
Y Lu, H Tian, H Peng, Q Wang, BA Bunnell… - Frontiers in Cell and …, 2024 - frontiersin.org
Introduction: Stem cells can be used to treat diabetic mellitus and complications. ω3-
docosahexaenoic acid (DHA) derived lipid mediators are inflammation-resolving and …
docosahexaenoic acid (DHA) derived lipid mediators are inflammation-resolving and …
Dendritic Cells for Type 1 Diabetes—Emerging Approaches for Tertiary Prevention
A Petrelli, CJ Rosen - NEJM evidence, 2024 - evidence.nejm.org
Type 1 diabetes is an autoimmune disease affecting genetically predisposed individuals that
leads to chronic hyperglycemia. It is well established that the disease progresses through …
leads to chronic hyperglycemia. It is well established that the disease progresses through …
Immune checkpoint inhibitors-induced diabetes mellitus
J Chen, X Hou, Y Yang, C Wang, J Zhou, J Miao… - Endocrine, 2024 - Springer
Immune checkpoint inhibitors (ICIs) have become extensively utilized in the early-stage
treatment of various cancers, offering additional therapeutic possibilities for patients with …
treatment of various cancers, offering additional therapeutic possibilities for patients with …
Mouse islet‐derived stellate cells are similar to, but distinct from, mesenchymal stromal cells and influence the beta cell function
W Xu, Y Zhou, T Wang, C Ni, C Wang, R Li… - Diabetic …, 2024 - Wiley Online Library
Aims Evidence is accumulating of the therapeutic benefits of mesenchymal stromal cells
(MSCs) in diabetes‐related conditions. We have identified a novel population of stromal …
(MSCs) in diabetes‐related conditions. We have identified a novel population of stromal …
Islet Like Cells Induced from Umbilical Cord Mesenchymal Stem Cells with Neonatal Bovine Pancreatic Mesenchymal Exosomes for Treatment of Diabetes Mellitus
F Yun, B Zhaorigen, X Han, X Li… - Hormone and Metabolic …, 2024 - thieme-connect.com
To investigate the safety and efficacy of the islet-like cell (cell) induced from human umbilical
cord mesenchymal stem cell (UCMSC) with different methods for the treatment of diabetic …
cord mesenchymal stem cell (UCMSC) with different methods for the treatment of diabetic …