Dopamine (DA) plays multiple roles in a wide range of physiological and pathological
processes via a large network of dopaminergic projections. To dissect the spatiotemporal …

Aging is a major risk factor for numerous chronic diseases. Vaccination offers a promising
strategy to combat these age-related diseases by targeting specific antigens and inducing …

A plethora of software suites and multiple classes of spectral libraries have been developed
to enhance the depth and robustness of data-independent acquisition (DIA) data …

The COVID-19 pandemic has had a profound impact on public mental health, leading to a
surge in loneliness, depression, and anxiety. And these public psychological issues …

Fetal stages are critical periods for brain development. However, the protein molecular
signature and dynamics of the human brain remain unclear due to sampling difficulty and …

G protein–coupled receptors (GPCRs) control critical cellular signaling pathways.
Therapeutic agents including anti-GPCR antibodies (Abs) are being developed to modulate …

Background Phobic anxiety present after stroke (called poststroke anxiety, PSA) can hamper
the rehabilitation of patients and disrupt their usual activities. Besides, the symptoms and …

The spleen is critical for immunity. It is the largest immune organ and immune center in the
peripheral system. While the relationship between behavior and immunity has been …

Depression is a prevalent mental disorder with a complex biological mechanism. Following
the rapid development of systems biology technology, a growing number of studies have …

Transmembrane (TM) proteins constitute over 30% of the mammalian proteome and play
essential roles in mediating cell-cell communication, synaptic transmission, and plasticity in …