Genomic imprinting in gametogenesis marks a subset of mammalian genes for parent‐of‐
origin‐dependent monoallelic expression in the offspring. Embryological and classical …

The molecular mechanisms introducing epigenetic modifications that lead to differential
silencing of some autosomal alleles depending on their parental legacy are still largely …

Alternative splicing (AS) plays a major role in the generation of proteomic diversity and in
gene regulation. However, the role of the basal splicing machinery in regulating AS remains …

Microdeletions of a region termed the" imprinting center"(IC) in chromosome 15q11-q13
have been identified in several families with Prader-Willi syndrome (PWS) or Angelman …

The human SNRPN (small nuclear ribonucleoprotein polypeptide N) gene is one of a gene
family that encode proteins involved in pre-mRNA splicing and maps to the smallest deletion …

The alternative splicing code that controls and coordinates the transcriptome in complex
multicellular organisms remains poorly understood. It has long been argued that regulation …

Polycistronic transcripts are common in prokaryotes but rare in eukaryotes. Phylogenetic
analysis of the SNRPN (SmN) mRNA in five eutherian mammals reveals a second highly …

Abstract Prader–Willi syndrome (PWS), a human neuroendocrine disorder, is associated
with deficiencies of paternal chromosome 15q12. Small nuclear ribonucleoprotein …

The SNRPN gene encodes a small nuclear ribonucleoprotein subunit, SmN, thought to be
Involved in spllcing of pre-mRNA. A closely related protein, SmB/B', Is constitutively …

Prader–Willi Syndrome (PWS) is a neurodevelopmental genetic disorder caused by loss of
expression of imprinted, paternally inherited genes on chromosome 15q11q13. This …