Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease

CK Negi, P Babica, L Bajard, J Bienertova-Vasku… - Metabolism, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
worldwide. With no Food and Drug Administration approved drugs, current treatment options …

[HTML][HTML] Fructose and NAFLD: the multifaceted aspects of fructose metabolism

P Jegatheesan, JP De Bandt - Nutrients, 2017 - mdpi.com
Among various factors, such as an unhealthy diet or a sedentarity lifestyle, excessive
fructose consumption is known to favor nonalcoholic fatty liver disease (NAFLD), as fructose …

Isocaloric diets high in animal or plant protein reduce liver fat and inflammation in individuals with type 2 diabetes

M Markova, O Pivovarova, S Hornemann, S Sucher… - Gastroenterology, 2017 - Elsevier
Background & Aims Nonalcoholic fatty liver disease (NAFLD) is associated with increased
risk of hepatic, cardiovascular, and metabolic diseases. High-protein diets, rich in …

[HTML][HTML] Pemafibrate, a new selective PPARα modulator: drug concept and its clinical applications for dyslipidemia and metabolic diseases

S Yamashita, D Masuda, Y Matsuzawa - Current atherosclerosis reports, 2020 - Springer
Abstract Purpose of Review Reduction of serum low-density lipoprotein cholesterol (LDL-C)
levels by statins, ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) …

[HTML][HTML] Epidemiology and pathophysiology of the association between NAFLD and metabolically healthy or metabolically unhealthy obesity

A Lonardo, A Mantovani, S Lugari, G Targher - Annals of hepatology, 2020 - Elsevier
The prevalence of nonalcoholic fatty liver disease (NAFLD) is continuing to rise in many
countries, paralleling the epidemic of obesity worldwide. In the last years, the concept of …

Fibroblast growth factor 21 in non-alcoholic fatty liver disease

B Tucker, H Li, X Long, KA Rye, KL Ong - Metabolism, 2019 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of pathologies ranging
from uncomplicated hepatic fat accumulation to a state of lobular inflammation and …

New developments in the biology of fibroblast growth factors

DM Ornitz, N Itoh - WIREs mechanisms of disease, 2022 - Wiley Online Library
The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Potential mechanisms underlying the ameliorative effect of Lactobacillus paracasei FZU103 on the lipid metabolism in hyperlipidemic mice fed a high-fat diet

XC Lv, M Chen, ZR Huang, WL Guo, LZ Ai… - Food Research …, 2021 - Elsevier
Lactobacillus paracasei FZU103, a probiotic previously isolated from the traditional brewing
process of Hongqu rice wine, may have the beneficial effect of improving the disorder of lipid …

[HTML][HTML] Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism

H Liu, D Peng - Endocrine Connections, 2022 - ec.bioscientifica.com
Hypothyroidism is often associated with elevated serum levels of total cholesterol, LDL-C
and triglycerides. Thyroid hormone (TH) affects the production, clearance and transformation …

Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity

MR Taskinen, S Söderlund, LH Bogl… - Journal of internal …, 2017 - Wiley Online Library
Background Overconsumption of dietary sugars, fructose in particular, is linked to
cardiovascular risk factors such as type 2 diabetes, obesity, dyslipidemia and nonalcoholic …