Targeting TGF-β signal transduction for fibrosis and cancer therapy
D Peng, M Fu, M Wang, Y Wei, X Wei - Molecular cancer, 2022 - Springer
Transforming growth factor β (TGF-β) has long been identified with its intensive involvement
in early embryonic development and organogenesis, immune supervision, tissue repair, and …
in early embryonic development and organogenesis, immune supervision, tissue repair, and …
TGF-β in hepatic stellate cell activation and liver fibrogenesis—updated 2019
Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …
The molecular mechanisms of liver fibrosis and its potential therapy in application
D Zhang, Y Zhang, B Sun - International Journal of Molecular Sciences, 2022 - mdpi.com
Liver fibrosis results from repeated and persistent liver damage. It can start with hepatocyte
injury and advance to inflammation, which recruits and activates additional liver immune …
injury and advance to inflammation, which recruits and activates additional liver immune …
Hepatic stellate cells and hepatocarcinogenesis
AE Barry, R Baldeosingh, R Lamm, K Patel… - Frontiers in cell and …, 2020 - frontiersin.org
Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma
(HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like …
(HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like …
Immunomodulatory role of the extracellular matrix within the liver disease microenvironment
CE McQuitty, R Williams, S Chokshi… - Frontiers in …, 2020 - frontiersin.org
Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …
[HTML][HTML] Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling
M Winkler, T Staniczek, SW Kürschner, CD Schmid… - Journal of …, 2021 - Elsevier
Background & Aims Angiocrine signaling by liver sinusoidal endothelial cells (LSECs)
regulates hepatic functions such as growth, metabolic maturation, and regeneration …
regulates hepatic functions such as growth, metabolic maturation, and regeneration …
Extra-and intra-cellular mechanisms of hepatic stellate cell activation
Y Yan, J Zeng, L Xing, C Li - Biomedicines, 2021 - mdpi.com
Hepatic fibrosis is characterized by the pathological accumulation of extracellular matrix
(ECM) in the liver resulting from the persistent liver injury and wound-healing reaction …
(ECM) in the liver resulting from the persistent liver injury and wound-healing reaction …
Extracellular matrix remodeling in chronic liver disease
C Ortiz, R Schierwagen, L Schaefer, S Klein… - Current tissue …, 2021 - Springer
Abstract Purpose of the Review This review aims to summarize the current knowledge of the
extracellular matrix remodeling during hepatic fibrosis. We discuss the diverse interactions …
extracellular matrix remodeling during hepatic fibrosis. We discuss the diverse interactions …
Identification of cancer stem cell characteristics in liver hepatocellular carcinoma by WGCNA analysis of transcriptome stemness index
KH Bai, SY He, LL Shu, WD Wang, SY Lin… - Cancer …, 2020 - Wiley Online Library
Cancer stem cells (CSCs) are characterized by self‐renewal and‐differential potential as
compared to common cancer cells and play an important role in the development and …
compared to common cancer cells and play an important role in the development and …
[HTML][HTML] Transforming growth factor β latency: A mechanism of cytokine storage and signalling regulation in liver homeostasis and disease
Y Li, W Fan, F Link, S Wang, S Dooley - JHEP Reports, 2022 - Elsevier
Transforming growth factor-β (TGF-β) is a potent effector in the liver, which is involved in a
plethora of processes initiated upon liver injury. TGF-β affects parenchymal, non …
plethora of processes initiated upon liver injury. TGF-β affects parenchymal, non …