Structure, function, and genetics of lipoprotein (a)

K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - ASBMB
Lipoprotein (a)[Lp (a)] has attracted the interest of researchers and physicians due to its
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …

Genetics of atherosclerosis

AJ Lusis, R Mar, P Pajukanta - Annu. Rev. Genomics Hum …, 2004 - annualreviews.org
▪ Abstract Atherosclerosis, the primary cause of coronary artery disease (CAD) and stroke, is
a disorder with multiple genetic and environmental contributions. Genetic-epidemiologic …

Frequency distributions of apolipoprotein (a) kringle IV repeat alleles and their effects on lipoprotein (a) levels in Caucasian, Asian, and African populations: the …

HG Kraft, A Lingenhel, RWC Pang, R Delport… - European Journal of …, 1996 - nature.com
Abstract A size polymorphism (K IV VNTR) and largely unknown sequence variation in the
apolipoprotein (a)[apo (a)] gene on chromosome 6q26–q27 together determine most of the …

The number of identical kringle IV repeats in apolipoprotein (a) affects its processing and secretion by HepG2 cells

C Brunner, EM Lobentanz, A Pethö-Schramm… - Journal of Biological …, 1996 - ASBMB
A variable number of 5.6-kilobase kringle IV repeats in the human apolipoprotein (a)(apo
(a)) gene results in a size polymorphism of the protein and correlates inversely with the …

Genome-wide association study of plasma lipoprotein (a) levels identifies multiple genes on chromosome 6q [S]

C Ober, AS Nord, EE Thompson, L Pan, Z Tan… - Journal of lipid …, 2009 - ASBMB
Plasma lipoprotein (a)(Lp [a]) level is an independent risk factor of cardiovascular disease
that is under strong genetic control. We conducted a genome-wide association study of …

[PDF][PDF] The Apo (a) gene is the major determinant of variation in plasma Lp (a) levels in African Americans

V Mooser, D Scheer, SM Marcovina, J Wang… - The American Journal of …, 1997 - cell.com
The distributions of plasma lipoprotein (a), or Lp (a), levels differ significantly among ethnic
groups. Individuals of African descent have a two-to threefold higher mean plasma level of …

The age dependency of gene expression for plasma lipids, lipoproteins, and apolipoproteins.

H Snieder, LJ Van Doornen… - American journal of …, 1997 - ncbi.nlm.nih.gov
The aim of this study was to investigate and disentangle the genetic and nongenetic causes
of stability and change in lipids and (apo) lipoproteins that occur during the lifespan. Total …

Molecular basis of congenital lp (a) deficiency: a frequent apo (a)'null'mutation in caucasians

M Ogorelkova, A Gruber… - Human molecular …, 1999 - academic.oup.com
High plasma concentrations of lipoprotein (a)[Lp (a)], a covalent low-density lipoprotein-
apolipoprotein (a)[apo (a)] complex, are associated with coronary heart disease and stroke …

Significant impact of the+ 93 C/T polymorphism in the apolipoprotein (a) gene on Lp (a) concentrations in Africans but not in Caucasians: confounding effect of linkage …

HG Kraft, M Windegger, HJ Menzel… - Human molecular …, 1998 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is a quantitative genetic trait in human plasma associated
with atherothrombotic disease. The major determinant of Lp (a) concentration is the …

Analysis of the apo (a) size polymorphism in Asian Indian populations: association with Lp (a) concentration and coronary heart disease

FS Geethanjali, K Luthra, A Lingenhel… - Atherosclerosis, 2003 - Elsevier
Most studies aiming to detect associations of genetic variation with common complex
diseases, eg coronary heart disease (CHD) have been performed in populations with a …