Background.—Coronary artery disease (CAD) is a major cause of morbidity and mortality in
most Western countries and its origin involves a significant genetic component. Methods …

High lipoprotein {a)[Lp (a)] plasma concentrations, which are genetically determined by apo
(a) size polymorphism, are directly associated with an increased risk for atherosclerosis …

Lp (a) concentrations are controlled primarily by genetic variation at LPA, the locus encoding
the unique protein apo (a). However, the high heritability is in part a consequence of nearly …

OBJECTIVE: Elevated serum levels of lipoprotein (a), a risk factor for atherosclerosis (AS),
are also associated with the presence of asymptomatic intracranial aneurysms. AS is …

Objective: Most reported mutations that affect lipoprotein metabolism are found within the
coding sequences of genes. Recently, a few mutations that occur within promoter …

Lipoprotein (a)[Lp (a)] is formed when apolipoprotein (a) is linked to low density lipoprotein
(LDL)-cholesterol via a single disulfide bond. It is an independent risk factor for myocardial …

A high serum concentration of lipoprotein (a)[Lp (a)] is a significant and independent risk
factor for cardiovascular disease. We examined the effects of agents on the transcriptional …

Like humans, baboons possess apolipoprotein [a](apo [a]), a unique protein component of
the atherogenic lipoprotein [a](Lp [a]) particle. Baboon apo [a] also exhibits extensive …

In this article, key events of the history of lipoprotein (a)(Lp (a)) research from its discovery as
a genetic trait in human plasma by the Norwegian scientist Kare Berg in 1963 until the …

Background: In addition to apolipoprotein (a)[apo (a)] kringle 4 variable number of tandem
repeat (K4-VNTR), pentanucleotide repeat polymorphism (PNRP) and C/T (+ 93) …