The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

A characteristic feature of the human airway epithelium is the presence of ciliated cells
bearing motile cilia, specialized cell surface projections containing axonemes composed of …

Rationale: There are no risk stratification tools for morbidity and mortality in bronchiectasis.
Identifying patients at risk of exacerbations, hospital admissions, and mortality is vital for …

Objectives We sought to describe the characteristics of adult patients with bronchiectasis
enrolled in the US Bronchiectasis Research Registry (BRR). Methods The BRR is a …

Patients with severe asthma represent a minority of the total asthma population, but carry a
majority of the morbidity and healthcare costs. Achieving better asthma control in this group …

Pseudomonas aeruginosa is responsible for chronic infection in many bronchiectasis
patients but it is not known whether it is associated with worse clinical outcomes …

Airway mucus is a complex viscoelastic gel that provides a defensive physical barrier and
shields the airway epithelium by trapping inhaled foreign pathogens and facilitating their …

Background People with non‐cystic fibrosis bronchiectasis commonly experience chronic
cough and sputum production, features that may be associated with progressive decline in …

Chronic respiratory diseases including chronic rhinosinusitis, otitis media, asthma, cystic
fibrosis, non-CF bronchiectasis, and chronic obstructive pulmonary disease are a major …

Bronchiectasis is one of the most neglected diseases in respiratory medicine. There are no
approved therapies and few large-scale, representative epidemiological studies. The …