The emergence of COVID-19 as a global pandemic: Understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2
An acute respiratory disease caused by a severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) that surfaced in China in late 2019, continues to spread rapidly across the …
(SARS-CoV-2) that surfaced in China in late 2019, continues to spread rapidly across the …
[HTML][HTML] Innate immune sensing of coronavirus and viral evasion strategies
The innate immune system is the first line of the host defense program against pathogens
and harmful substances. Antiviral innate immune responses can be triggered by multiple …
and harmful substances. Antiviral innate immune responses can be triggered by multiple …
[HTML][HTML] The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak–an update on the status
YR Guo, QD Cao, ZS Hong, YY Tan, SD Chen… - Military medical …, 2020 - Springer
An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously
known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout …
known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout …
[HTML][HTML] SARS-CoV-2 membrane protein inhibits type I interferon production through ubiquitin-mediated degradation of TBK1
L Sui, Y Zhao, W Wang, P Wu, Z Wang, Y Yu… - Frontiers in …, 2021 - frontiersin.org
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative
pathogen of current COVID-19 pandemic, and insufficient production of type I interferon (IFN …
pathogen of current COVID-19 pandemic, and insufficient production of type I interferon (IFN …
[HTML][HTML] Severe COVID-19, another piece in the puzzle of the hyperferritinemic syndrome. An immunomodulatory perspective to alleviate the storm
P Ruscitti, O Berardicurti, P Di Benedetto… - Frontiers in …, 2020 - frontiersin.org
The coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by severe
acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has been declared as a …
acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has been declared as a …
[HTML][HTML] Identification of poly (ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells
Innate immune cells are critical in protective immunity against viral infections, involved in
sensing foreign viral nucleic acids. Here we report that the poly (ADP-ribose) polymerase 9 …
sensing foreign viral nucleic acids. Here we report that the poly (ADP-ribose) polymerase 9 …
[HTML][HTML] Understanding COVID-19 in children: immune determinants and post-infection conditions
Coronavirus disease 2019 in children presents with milder clinical manifestations than in
adults. On the other hand, the presence of a wide range of inflammatory manifestations …
adults. On the other hand, the presence of a wide range of inflammatory manifestations …
The role and function of Fcγ receptors on myeloid cells
S Bournazos, TT Wang… - Myeloid Cells in Health and …, 2017 - Wiley Online Library
A key determinant for the survival of an organism is the ability to recognize and respond to
invading pathogens without damaging host tissues. This is accomplished largely by the …
invading pathogens without damaging host tissues. This is accomplished largely by the …
[HTML][HTML] Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27
Q Zheng, J Hou, Y Zhou, Y Yang, B Xie, X Cao - Cell research, 2015 - nature.com
Type I interferon (IFN) production plays pivotal roles in host antiviral innate immune
responses, but an excessive production of type I IFN leads to the development of …
responses, but an excessive production of type I IFN leads to the development of …
The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication
MicroRNAs (miRNAs) are small noncoding RNAs that are responsible for dynamic changes
in gene expression, and some regulate innate antiviral responses. Retinoic acid–inducible …
in gene expression, and some regulate innate antiviral responses. Retinoic acid–inducible …