Numerical study of nanoscale and microscale particle transport in realistic lung models with and without stenosis
The transport and deposition (TD) of inhaled aerosol particles in airways of human lungs are
important for therapeutically targeted drug delivery in respiratory tracts. The airflow and …
important for therapeutically targeted drug delivery in respiratory tracts. The airflow and …
[HTML][HTML] Evaluation of human obstructive sleep apnea using computational fluid dynamics
S Taherian, H Rahai, S Lopez, J Shin… - Communications biology, 2019 - nature.com
Obstructive sleep apnea (OSA) severity might be correlated to the flow characteristics of the
upper airways. We aimed to investigate the severity of OSA based on 3D models …
upper airways. We aimed to investigate the severity of OSA based on 3D models …
Orally inhaled drug particle transport in computerized models of laryngotracheal stenosis
DO Frank-Ito, SM Cohen - Otolaryngology–Head and Neck …, 2021 - journals.sagepub.com
Objective Adjuvant management for laryngotracheal stenosis (LTS) may involve inhaled
corticosteroids, but metered dose inhalers are designed for pulmonary drug delivery …
corticosteroids, but metered dose inhalers are designed for pulmonary drug delivery …
Drug delivery to the pediatric upper airway
SAA Ghavimi, PM Gehret, MR Aronson… - Advanced Drug Delivery …, 2021 - Elsevier
Pediatric upper airway disorders are frequently life-threatening and require precise
assessment and intervention. Targeting these pathologies remains a challenge for clinicians …
assessment and intervention. Targeting these pathologies remains a challenge for clinicians …
Tracheomalacia reduces aerosolized drug delivery to the lung
CC Gunatilaka, C McKenzie, EB Hysinger… - Journal of Aerosol …, 2024 - liebertpub.com
Rationale: Neonates with respiratory issues are frequently treated with aerosolized
medications to manage lung disease or facilitate airway clearance. Dynamic tracheal …
medications to manage lung disease or facilitate airway clearance. Dynamic tracheal …
[HTML][HTML] A Novel Trans-Tracheostomal Retrograde Inhalation Technique Increases Subglottic Drug Deposition Compared to Traditional Trans-Oral Inhalation
Subglottic stenosis represents a challenging clinical condition in otolaryngology. Although
patients often experience improvement following endoscopic surgery, recurrence rates …
patients often experience improvement following endoscopic surgery, recurrence rates …
[HTML][HTML] Effect of cartilaginous rings in tracheal flow with stenosis
H Bocanegra Evans, JM Segnini, A Doosttalab… - BMC Biomedical …, 2023 - Springer
Background In respiratory fluid dynamics research, it is typically assumed that the wall of the
trachea is smooth. However, the trachea is structurally supported by a series of cartilaginous …
trachea is smooth. However, the trachea is structurally supported by a series of cartilaginous …
Fluid dynamic assessment of tracheal flow in infants with congenital tracheal stenosis before and after surgery
Tracheal flow in infants with congenital tracheal stenosis (CTS) was numerically investigated
using subject-specific airway models before and after reconstructive surgery. We quantified …
using subject-specific airway models before and after reconstructive surgery. We quantified …
[HTML][HTML] Computational fluid dynamic analysis of the pharyngeal airway after bimaxillary orthognathic surgery in patients with mandibular prognathism
This study aimed to analyze pharyngeal airflow characteristics and their relationship with the
skeletal movement of the maxilla and mandible after bimaxillary orthognathic surgery in …
skeletal movement of the maxilla and mandible after bimaxillary orthognathic surgery in …
Computational Analysis of the Particles Matter in the Respiratory Tract of Children
Abstract According to the World Health Organization, unhealthy air causes respiratory and
cardiovascular diseases worldwide, moreover, children are particularly susceptible and …
cardiovascular diseases worldwide, moreover, children are particularly susceptible and …