Numerical study of nanoscale and microscale particle transport in realistic lung models with and without stenosis

MM Rahman, M Zhao, MS Islam, K Dong… - International Journal of …, 2021 - Elsevier
The transport and deposition (TD) of inhaled aerosol particles in airways of human lungs are
important for therapeutically targeted drug delivery in respiratory tracts. The airflow and …

[HTML][HTML] Evaluation of human obstructive sleep apnea using computational fluid dynamics

S Taherian, H Rahai, S Lopez, J Shin… - Communications biology, 2019 - nature.com
Obstructive sleep apnea (OSA) severity might be correlated to the flow characteristics of the
upper airways. We aimed to investigate the severity of OSA based on 3D models …

Orally inhaled drug particle transport in computerized models of laryngotracheal stenosis

DO Frank-Ito, SM Cohen - Otolaryngology–Head and Neck …, 2021 - journals.sagepub.com
Objective Adjuvant management for laryngotracheal stenosis (LTS) may involve inhaled
corticosteroids, but metered dose inhalers are designed for pulmonary drug delivery …

Drug delivery to the pediatric upper airway

SAA Ghavimi, PM Gehret, MR Aronson… - Advanced Drug Delivery …, 2021 - Elsevier
Pediatric upper airway disorders are frequently life-threatening and require precise
assessment and intervention. Targeting these pathologies remains a challenge for clinicians …

Tracheomalacia reduces aerosolized drug delivery to the lung

CC Gunatilaka, C McKenzie, EB Hysinger… - Journal of Aerosol …, 2024 - liebertpub.com
Rationale: Neonates with respiratory issues are frequently treated with aerosolized
medications to manage lung disease or facilitate airway clearance. Dynamic tracheal …

[HTML][HTML] A Novel Trans-Tracheostomal Retrograde Inhalation Technique Increases Subglottic Drug Deposition Compared to Traditional Trans-Oral Inhalation

R Allon, S Bhardwaj, J Sznitman, H Shoffel-Havakuk… - Pharmaceutics, 2023 - mdpi.com
Subglottic stenosis represents a challenging clinical condition in otolaryngology. Although
patients often experience improvement following endoscopic surgery, recurrence rates …

[HTML][HTML] Effect of cartilaginous rings in tracheal flow with stenosis

H Bocanegra Evans, JM Segnini, A Doosttalab… - BMC Biomedical …, 2023 - Springer
Background In respiratory fluid dynamics research, it is typically assumed that the wall of the
trachea is smooth. However, the trachea is structurally supported by a series of cartilaginous …

Fluid dynamic assessment of tracheal flow in infants with congenital tracheal stenosis before and after surgery

N Takeishi, T Miki, T Otani, S Ii, K Morita… - Medical & Biological …, 2019 - Springer
Tracheal flow in infants with congenital tracheal stenosis (CTS) was numerically investigated
using subject-specific airway models before and after reconstructive surgery. We quantified …

[HTML][HTML] Computational fluid dynamic analysis of the pharyngeal airway after bimaxillary orthognathic surgery in patients with mandibular prognathism

P Wadhwa, HS Jang, SH Park, HH Kim, ES Lee - Processes, 2021 - mdpi.com
This study aimed to analyze pharyngeal airflow characteristics and their relationship with the
skeletal movement of the maxilla and mandible after bimaxillary orthognathic surgery in …

Computational Analysis of the Particles Matter in the Respiratory Tract of Children

G Suárez, JA Niño, JD Hoyos, CA Paramo… - … Conference on Smart …, 2021 - Springer
Abstract According to the World Health Organization, unhealthy air causes respiratory and
cardiovascular diseases worldwide, moreover, children are particularly susceptible and …