The direct or indirect targeting of antibody Fc receptors (FcRs) presents unique opportunities
and interesting challenges for the treatment of inflammatory diseases, cancer and infection …

TNFR1 and TNFR2 have received prominent attention because of their dominance in the
pathogenesis of inflammation and autoimmunity. TNFR1 has been extensively studied and …

TUMOUR necrosis factor-α (TNF-α) is a potent pro-inflammatory and immunomodulatory
cytokine implicated in inflammatory conditions such as rheumatoid arthritis, Crohn's disease …

The most studied biological role of type III interferons (IFNs) has so far been their antiviral
activity, but their role in autoimmune and inflammatory diseases remains largely unexplored …

Two tumor necrosis factor (TNF) antagonists infliximab (a chimeric monoclonal antibody)
and etanercept (a p75 TNF receptor/Fc fusion protein) have been approved for treatment of …

Neutrophils are prominent participants in the joint inflammation of human rheumatoid
arthritis (RA) patients, but the extent of their role in the inductive phase of joint inflammation …

As a medical student in the late 1960s in Australia, I realized that we knew very little about
the mechanisms of disease, and I was eager to learn more. In Melbourne, the premier …

Cytokines such as tumor necrosis factor (TNF) are expressed at high levels in rheumatoid
joint tissue, where they contribute significantly to inflammation and articular destruction. TNF …

IL-18 is a novel cytokine with pleiotropic activities critical to the development of T-helper 1
(Th1) responses. We detected IL-18 mRNA and protein within rheumatoid arthritis (RA) …

Myeloid-derived suppressor cells (MDSCs) are heterogenous populations of immature
myeloid progenitor cells with immunoregulatory function. MDSCs play critical roles in …