Rheumatoid arthritis is a multisystemic auto-inflammatory disease affecting up to 1% of the
population and leading to the destruction of the joints. Evidence exists for the involvement of …

Galectin-1 (GAL-1), a member of a family of conserved β-galactoside–binding proteins, has
been shown to induce in vitro apoptosis of activated T cells and immature thymocytes. We …

Collagen induced arthritis (CIA) is an autoimmune model that in many ways resembles
rheumatoid arthritis (RA). Immunization of genetically susceptible strains of rodents and …

The cytokines TNF and IL‐1 have been implicated as mediators of the inflammatory
processes in patients with inflammatory bowel disease (IBD). To investigate the role of these …

Secretion of tumor necrosis factor-α (TNF-α) by macrophages plays a predominant role in
the development and progression of rheumatoid arthritis. We demonstrate that knockdown of …

▪ Abstract Tumor necrosis factor α (TNFα) and interleukin-1 (IL-1) are important in mediating
inflammation in rheumatoid arthritis (RA). Randomized phase II and III clinical trials of anti …

Tumor necrosis factor (TNF) is an inflammatory cytokine that has important roles in various
immune responses, which are mediated through its two receptors, TNF receptor 1 (TNFR1) …

Introduction Post-traumatic arthritis (PTA) is a progressive, degenerative response to joint
injury, such as articular fracture. The pro-inflammatory cytokines, interleukin 1 (IL-1) and …

Objective. To examine the role of tumor necrosis factor α (TNFα), interleukin‐1α (IL‐1α), and
IL‐1β in collagen‐induced arthritis (CIA), immediately after onset and during the phase of …

The tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) induces apoptosis of
tumor cells but not normal cells; its role in normal nontransformed tissues is unknown. We …