Objective. Biological products that neutralize tumour necrosis factor α (TNF‐α) are beneficial
in rheumatoid arthritis (RA). We studied the effects of CDP870, a novel anti‐TNF‐α antibody …

Tumor necrosis factor (TNF) alpha is a cytokine that has potent immune regulatory functions.
To assess the potential role of this cytokine in the early development of autoimmunity, we …

Rheumatoid arthritis (RA) is a chronic inflammatory disease in which the progressive
destruction of joint causes morbidity. It is also associated with an increased risk of …

Objective To clarify the role of interleukin‐6 (IL‐6) in the pathogenesis of collagen‐induced
arthritis (CIA). Methods CIA was induced by immunizing twice at a 3‐week interval with …

Monoclonal antibodies (mAbs) are immunoglobulins designed to target a specific epitope on
an antigen. Immunoglobulins of identical amino-acid sequence were originally produced by …

Repeated injections of adult mice with recombinant murine TNF prolong the survival of
NZB/W F1 mice, and suppress type I insulin-dependent diabetes mellitus (IDDM) in …

Numerous recent investigations have pointed to a key role of the proinflammatory,
pleiotropic cytokine tumor necrosis factor‐α (TNF‐α) in host defense and inflammatory …

Introduction The aim of this study was to compare the effects of tumour necrosis factor-alpha
(TNF-α) and interleukin-1-beta (IL-1β) on protease and catabolic cytokine and receptor gene …

The TNF/TNF receptor (TNFR) system has a prominent role in the pathogenesis of chronic
inflammatory and autoimmune disorders. Extensive research in animal models with …

Interest in the role of free radicals in rheumatoid arthritis (RA) stems from the seminal work of
McCord,'who noted the decreased viscosity of synovial fluid in RA patients and showed that …