Significant effects of renal function on mycophenolic acid total clearance in pediatric kidney transplant recipients with population pharmacokinetic modeling
Abstract Background and Objectives Mycophenolic acid (MPA) is an immunosuppressant
commonly prescribed in pediatric kidney transplantation to prevent graft rejection. Large …
commonly prescribed in pediatric kidney transplantation to prevent graft rejection. Large …
A pediatric perspective on genomics and prevention in the twenty-first century
We present evidence from diverse disciplines and populations to identify the current and
emerging role of genomics in prevention from both medical and public health perspectives …
emerging role of genomics in prevention from both medical and public health perspectives …
Molecular targets in advanced therapeutics of cancers: the role of pharmacogenetics
MB Abubakar, SH Gan - Oncology, 2016 - karger.com
The advent of advanced molecular targeted therapy has resulted in improved prognoses for
patients with advanced malignancies. However, despite the significant success and …
patients with advanced malignancies. However, despite the significant success and …
CYP3A5 genotype affects time to therapeutic tacrolimus level in pediatric kidney transplant recipients
MV Yanik, ME Seifert, JE Locke… - Pediatric …, 2019 - Wiley Online Library
Background Optimal management of immunosuppression in kidney transplantation requires
a delicate balance of efficacy and toxicity. Tacrolimus (TAC) dose requirements are …
a delicate balance of efficacy and toxicity. Tacrolimus (TAC) dose requirements are …
CYP3A5 genotype and time to reach tacrolimus therapeutic levels in renal transplant children
AC Alvarez-Elías, P García-Roca… - Transplantation …, 2016 - Elsevier
Background CYP3A5 gene polymorphism rs776746 has been associated with lower
tacrolimus dose requirements and bioavailability in both adults and children. This variant …
tacrolimus dose requirements and bioavailability in both adults and children. This variant …
Medication-induced nephrotoxicity in children
J Tjon, CW Teoh - Current Pediatrics Reports, 2020 - Springer
Abstract Purpose of Review The purpose of this article is to review common mechanisms of
drug-induced nephrotoxicity (DIN) while highlighting some of the common medications in …
drug-induced nephrotoxicity (DIN) while highlighting some of the common medications in …
Nephrology in Mexico
G Garcia-Garcia, JS Chavez-Iñiguez… - Nephrology …, 2021 - Springer
Nephrology in Mexico started in 1955 with the opening of the nephrology department at
Mexico's National Heart Institute, where the first nephrology training program began in 1958 …
Mexico's National Heart Institute, where the first nephrology training program began in 1958 …
Potential of B-cell-targeting therapy in overcoming multidrug resistance and tissue invasiveness associated with P-glycoprotein expressing-B cell compartments
S Tsujimura, Y Tanaka - Immunological Medicine, 2021 - Taylor & Francis
Rheumatoid arthritis (RA) is a systemic autoimmune mediated inflammatory disease
characterized by progressive joint damage and extra-articular organ manifestations. Among …
characterized by progressive joint damage and extra-articular organ manifestations. Among …
基因多态性对儿童霉酚酸酯个体化治疗的意义
张致庆 - 临床儿科杂志, 2018 - jcp.xinhuamed.com.cn
霉酚酸酯(MMF) 在器官移植等临床治疗上发挥重要的免疫抑制作用. 但由于个体间遗传背景等
因素的差异, 固定剂量给药并不能获得有效安全的MMF 血药浓度, 无法满足个体化治疗的需要 …
因素的差异, 固定剂量给药并不能获得有效安全的MMF 血药浓度, 无法满足个体化治疗的需要 …
Pharmacogenomics: recent progress, sex gender differences, translation into clinical practice, application in pediatrics and future perspectives
Pharmacogenomics is a promising field which increasingly influences medicine and
biomedical research in many areas. Aim of this article is to provide a comprehensive review …
biomedical research in many areas. Aim of this article is to provide a comprehensive review …