The partial cross-utilization of molecules and pathways involved in opposing processes like
cell survival, proliferation and cell death, assures that mutations within one signaling …

Focal adhesion kinase (FAK) is a non‐receptor cytoplasmic tyrosine kinase that plays a key
role in the regulation of proliferation and migration of normal and tumor cells. FAK …

Glioblastoma multiforme (GBM), the most common and malignant central nervous system
tumor in humans, is highly proliferative and resistant to apoptosis. Stat3, a latent …

Background Astrocytomas are the most common type of primary central nervous system
tumors. They are frequently associated with genetic mutations that deregulate cell cycle and …

The multistep nature of cancer development provides a rationale for cancer prevention.
Activation of oncogenes, inactivation of tumor suppressor genes and modulation of …

Histone methylation is the important transcription regulatory system that affects mammalian
development and cell differentiation. Alterations in epigenetic gene regulation are …

The prolonged duration requiring alteration of multi-genetic and epigenetic molecular events
for cancer development provides a strong rationale for cancer prevention, which is …

Integrating large-scale functional genomic data has significantly accelerated our
understanding of gene functions. However, no algorithm has been developed to differentiate …

Glioblastoma Multiforme (GBM) is recognized as one of the most deadly cancers
characterized by cellular atypia, severe necrosis, and high rate of angiogenesis. In this …

9p21 locus is one of the most reproducible regions in genome-wide association studies
(GWAS). The region harbors CDKN2A/B genes that code for p16INK4a, p15INK4b, and …